The BLAST website at the National Center for Biotechnology Information (NCBI) has been improved to enhance usability and efficiency. The new BLAST report allows faster loading of alignments, includes navigation aids, and enables easy downloading of subject sequences and reports. It also addresses usability issues in the previous report. The report is redesigned to be more user-friendly, flexible, and efficient. The new report uses asynchronous JavaScript (AJAX) to format alignments as needed, allowing quick loading of alignments for the top five subject sequences. Users can navigate through alignments by scrolling, selecting titles, or using the BLAST Graphical Overview. The new report also provides additional download options, such as FASTA, GenBank, and various BLAST reports, and includes links to other NCBI resources like the graphical sequence viewer and distance tree. The report also includes a table of descriptions that can be sorted and customized. The new report has improved navigation aids, including 'next', 'previous', and 'descriptions' for moving between alignments and back to the table of descriptions. The report also includes a new system ('blastdb_info') to store metadata for BLAST databases, including database specifications, sequence types, organism information, and comments. Other improvements include a redesigned search page that is more consistent across different BLAST search pages, making it easier for users to navigate between them. The NCBI plans to continue improving the BLAST website, including adding new columns to the descriptions table and making blastdb_info searchable through a web interface. The BLAST help tab provides links to a video and a document about using the new BLAST report. The authors acknowledge the contributions of various individuals and institutions, and the study was funded by the Intramural Research Program of the National Institutes of Health and the National Library of Medicine.The BLAST website at the National Center for Biotechnology Information (NCBI) has been improved to enhance usability and efficiency. The new BLAST report allows faster loading of alignments, includes navigation aids, and enables easy downloading of subject sequences and reports. It also addresses usability issues in the previous report. The report is redesigned to be more user-friendly, flexible, and efficient. The new report uses asynchronous JavaScript (AJAX) to format alignments as needed, allowing quick loading of alignments for the top five subject sequences. Users can navigate through alignments by scrolling, selecting titles, or using the BLAST Graphical Overview. The new report also provides additional download options, such as FASTA, GenBank, and various BLAST reports, and includes links to other NCBI resources like the graphical sequence viewer and distance tree. The report also includes a table of descriptions that can be sorted and customized. The new report has improved navigation aids, including 'next', 'previous', and 'descriptions' for moving between alignments and back to the table of descriptions. The report also includes a new system ('blastdb_info') to store metadata for BLAST databases, including database specifications, sequence types, organism information, and comments. Other improvements include a redesigned search page that is more consistent across different BLAST search pages, making it easier for users to navigate between them. The NCBI plans to continue improving the BLAST website, including adding new columns to the descriptions table and making blastdb_info searchable through a web interface. The BLAST help tab provides links to a video and a document about using the new BLAST report. The authors acknowledge the contributions of various individuals and institutions, and the study was funded by the Intramural Research Program of the National Institutes of Health and the National Library of Medicine.