BRIG is a user-friendly, cross-platform desktop application for visualizing prokaryote genome comparisons. It generates circular images showing multiple genome comparisons, with similarity between a central reference sequence and other sequences represented as concentric rings colored by BLAST identity. BRIG can handle draft or complete genomes and supports custom annotations, read coverage, and assembly breakpoints. It uses BLAST for genome comparisons and CGView for image rendering, with a graphical user interface that allows users to specify settings and generate images without requiring command-line knowledge. BRIG is freely available for all operating systems and can be used to compare large numbers of genomes, including unassembled data. It supports read mapping against a central reference sequence and can display various types of custom data. BRIG is versatile, allowing users to visualize genome comparisons, including presence/absence of genes, read coverage, and contig boundaries. It is designed for ease of use and is suitable for both researchers and non-experts. BRIG is maintained and includes tutorials and sample data. It is available at http://sourceforge.net/projects/brig/.BRIG is a user-friendly, cross-platform desktop application for visualizing prokaryote genome comparisons. It generates circular images showing multiple genome comparisons, with similarity between a central reference sequence and other sequences represented as concentric rings colored by BLAST identity. BRIG can handle draft or complete genomes and supports custom annotations, read coverage, and assembly breakpoints. It uses BLAST for genome comparisons and CGView for image rendering, with a graphical user interface that allows users to specify settings and generate images without requiring command-line knowledge. BRIG is freely available for all operating systems and can be used to compare large numbers of genomes, including unassembled data. It supports read mapping against a central reference sequence and can display various types of custom data. BRIG is versatile, allowing users to visualize genome comparisons, including presence/absence of genes, read coverage, and contig boundaries. It is designed for ease of use and is suitable for both researchers and non-experts. BRIG is maintained and includes tutorials and sample data. It is available at http://sourceforge.net/projects/brig/.