This randomized, controlled study evaluated the effects of perioperative celecoxib administration on pain management and rehabilitative outcomes after total knee arthroplasty (TKA). Eighty patients were divided into two groups: the study group received a single 400 mg dose of celecoxib one hour before surgery, followed by 200 mg every 12 hours for five days, along with patient-controlled analgesia (PCA) morphine. The control group received only PCA morphine. The study found that the study group had significantly lower resting VAS pain scores at 48 and 72 hours post-surgery, increased active range of motion (ROM) in the first three days, and reduced opioid requirements by about 40%. Postoperative nausea and vomiting were also reduced, although not significantly. There were no significant differences in blood loss or the need for blood transfusions between the groups. The study concluded that perioperative celecoxib, combined with opioids, is an effective and safe regimen for pain control in TKA patients, improving postoperative pain scores and ROM while reducing opioid use.This randomized, controlled study evaluated the effects of perioperative celecoxib administration on pain management and rehabilitative outcomes after total knee arthroplasty (TKA). Eighty patients were divided into two groups: the study group received a single 400 mg dose of celecoxib one hour before surgery, followed by 200 mg every 12 hours for five days, along with patient-controlled analgesia (PCA) morphine. The control group received only PCA morphine. The study found that the study group had significantly lower resting VAS pain scores at 48 and 72 hours post-surgery, increased active range of motion (ROM) in the first three days, and reduced opioid requirements by about 40%. Postoperative nausea and vomiting were also reduced, although not significantly. There were no significant differences in blood loss or the need for blood transfusions between the groups. The study concluded that perioperative celecoxib, combined with opioids, is an effective and safe regimen for pain control in TKA patients, improving postoperative pain scores and ROM while reducing opioid use.