The article reviews the role of bacterial quorum sensing in pathogenic relationships, focusing on the use of autoinducers (AIs) for cell-to-cell communication. Quorum sensing allows bacteria to coordinate their behavior based on population density, enabling them to migrate to better environments, sporulate, or form biofilms. The review highlights the importance of quorum sensing in the virulence of pathogens such as *Pseudomonas aeruginosa*, *Burkholderia cepacia*, *Erwinia carotovora*, and *Agrobacterium tumefaciens*. These bacteria use different AIs, primarily N-acyl homoserine lactones (AHLs), to regulate gene expression and virulence factors. The review also discusses the potential of targeting quorum sensing for antimicrobial therapy, including the use of AHL analogs and enzymes that degrade AHLs. Additionally, it explores the role of quorum sensing in biofilm formation and its applications in biological control in agriculture. The findings suggest that blocking quorum sensing could be a promising strategy for preventing infections and managing plant diseases.The article reviews the role of bacterial quorum sensing in pathogenic relationships, focusing on the use of autoinducers (AIs) for cell-to-cell communication. Quorum sensing allows bacteria to coordinate their behavior based on population density, enabling them to migrate to better environments, sporulate, or form biofilms. The review highlights the importance of quorum sensing in the virulence of pathogens such as *Pseudomonas aeruginosa*, *Burkholderia cepacia*, *Erwinia carotovora*, and *Agrobacterium tumefaciens*. These bacteria use different AIs, primarily N-acyl homoserine lactones (AHLs), to regulate gene expression and virulence factors. The review also discusses the potential of targeting quorum sensing for antimicrobial therapy, including the use of AHL analogs and enzymes that degrade AHLs. Additionally, it explores the role of quorum sensing in biofilm formation and its applications in biological control in agriculture. The findings suggest that blocking quorum sensing could be a promising strategy for preventing infections and managing plant diseases.