This study investigates the challenges and strategies for balancing patient confidentiality and effective care coordination in the digital age, focusing on the experiences of nurses in a general hospital in Egypt. A cross-sectional study involving 150 nurses collected data using six tools: Demographic Form, HIPAA Compliance Checklist, Privacy Impact Assessment (PIA) Tool, Data Sharing Agreement (DSA) Framework, EHR Privacy and Security Assessment Tool, and NIST Cybersecurity Framework. Validity and reliability were ensured through pilot testing and factor analysis. The results showed high compliance with HIPAA regulations, particularly in administrative and technical safeguards, and strong performance in privacy management and data security. Strong positive correlations were found between HIPAA Compliance and EHR Privacy, as well as between HIPAA Compliance and NIST Cybersecurity. The study concludes that continuous training and comprehensive privacy frameworks are essential for enhancing patient confidentiality and supporting effective care coordination. The findings highlight the need for robust data protection practices, clear guidelines, and support systems to help nurses navigate the complex balance between confidentiality and care coordination. The study also emphasizes the importance of technological solutions, comprehensive policies, and active patient engagement in ensuring patient privacy while facilitating the necessary flow of information for care coordination. The results suggest that healthcare providers should invest in ongoing education and training for nurses, upgrade physical security measures, and standardise consent management practices to improve data security and patient outcomes. The study underscores the importance of a multifaceted approach that includes technological solutions, comprehensive policies, ongoing education, and active patient engagement to address the challenges of balancing confidentiality and care coordination in the digital age.This study investigates the challenges and strategies for balancing patient confidentiality and effective care coordination in the digital age, focusing on the experiences of nurses in a general hospital in Egypt. A cross-sectional study involving 150 nurses collected data using six tools: Demographic Form, HIPAA Compliance Checklist, Privacy Impact Assessment (PIA) Tool, Data Sharing Agreement (DSA) Framework, EHR Privacy and Security Assessment Tool, and NIST Cybersecurity Framework. Validity and reliability were ensured through pilot testing and factor analysis. The results showed high compliance with HIPAA regulations, particularly in administrative and technical safeguards, and strong performance in privacy management and data security. Strong positive correlations were found between HIPAA Compliance and EHR Privacy, as well as between HIPAA Compliance and NIST Cybersecurity. The study concludes that continuous training and comprehensive privacy frameworks are essential for enhancing patient confidentiality and supporting effective care coordination. The findings highlight the need for robust data protection practices, clear guidelines, and support systems to help nurses navigate the complex balance between confidentiality and care coordination. The study also emphasizes the importance of technological solutions, comprehensive policies, and active patient engagement in ensuring patient privacy while facilitating the necessary flow of information for care coordination. The results suggest that healthcare providers should invest in ongoing education and training for nurses, upgrade physical security measures, and standardise consent management practices to improve data security and patient outcomes. The study underscores the importance of a multifaceted approach that includes technological solutions, comprehensive policies, ongoing education, and active patient engagement to address the challenges of balancing confidentiality and care coordination in the digital age.