This study investigates the challenges and strategies for balancing patient confidentiality and effective care coordination in the digital age, focusing on nurses' experiences. A cross-sectional study was conducted in a general hospital in Egypt, involving 150 nurses with at least six months of experience. Data were collected using six tools: Demographic Form, HIPAA Compliance Checklist, Privacy Impact Assessment (PIA) Tool, Data Sharing Agreement (DSA) Framework, EHR Privacy and Security Assessment Tool, and NIST Cybersecurity Framework. The results showed high compliance with HIPAA regulations, particularly in administrative and technical safeguards, and strong performance in project descriptions and data storage strategies. However, variability in physical safeguards, organizational requirements, and detection measures highlighted areas for improvement. Significant correlations were found between HIPAA Compliance and EHR Privacy, as well as NIST Cybersecurity, indicating the interconnectedness of regulatory compliance and proactive privacy measures. The study recommends continuous training for nurses, standardized consent management practices, regular audits, and fostering a culture of continuous improvement in healthcare organizations. These findings offer actionable insights for healthcare practice, policy, and future research, emphasizing the need for comprehensive training, detailed guidelines, and longitudinal studies to address evolving digital health challenges.This study investigates the challenges and strategies for balancing patient confidentiality and effective care coordination in the digital age, focusing on nurses' experiences. A cross-sectional study was conducted in a general hospital in Egypt, involving 150 nurses with at least six months of experience. Data were collected using six tools: Demographic Form, HIPAA Compliance Checklist, Privacy Impact Assessment (PIA) Tool, Data Sharing Agreement (DSA) Framework, EHR Privacy and Security Assessment Tool, and NIST Cybersecurity Framework. The results showed high compliance with HIPAA regulations, particularly in administrative and technical safeguards, and strong performance in project descriptions and data storage strategies. However, variability in physical safeguards, organizational requirements, and detection measures highlighted areas for improvement. Significant correlations were found between HIPAA Compliance and EHR Privacy, as well as NIST Cybersecurity, indicating the interconnectedness of regulatory compliance and proactive privacy measures. The study recommends continuous training for nurses, standardized consent management practices, regular audits, and fostering a culture of continuous improvement in healthcare organizations. These findings offer actionable insights for healthcare practice, policy, and future research, emphasizing the need for comprehensive training, detailed guidelines, and longitudinal studies to address evolving digital health challenges.