Balancing forces: architectural control of mechanotransduction

Balancing forces: architectural control of mechanotransduction

2011 May ; 12(5): 308–319. | Christopher C. DuFort, Matthew J. Paszek, and Valerie M. Weaver
The article "Balancing Forces: Architectural Control of Mechanotransduction" by Christopher C. DuFort, Matthew J. Paszek, and Valerie M. Weaver, published in *Nature Reviews Molecular Cell Biology*, explores the intricate relationship between mechanical forces and cellular function. The authors highlight how cells respond to mechanical cues from their environment, such as the extracellular matrix (ECM), and how these responses are integrated to maintain tissue homeostasis and function. They discuss the role of integrins and focal adhesions in sensing and transducing mechanical signals, and how these mechanisms are influenced by the physical properties of the ECM. The article also delves into the dynamic nature of the ECM, which can serve as a memory storage device, influencing cell behavior over long periods. The authors emphasize the importance of understanding the interplay between mechanical and biochemical signals in diseases like cancer and cardiovascular disease, and propose that a comprehensive mechanoochemical perspective is necessary for developing effective treatments.The article "Balancing Forces: Architectural Control of Mechanotransduction" by Christopher C. DuFort, Matthew J. Paszek, and Valerie M. Weaver, published in *Nature Reviews Molecular Cell Biology*, explores the intricate relationship between mechanical forces and cellular function. The authors highlight how cells respond to mechanical cues from their environment, such as the extracellular matrix (ECM), and how these responses are integrated to maintain tissue homeostasis and function. They discuss the role of integrins and focal adhesions in sensing and transducing mechanical signals, and how these mechanisms are influenced by the physical properties of the ECM. The article also delves into the dynamic nature of the ECM, which can serve as a memory storage device, influencing cell behavior over long periods. The authors emphasize the importance of understanding the interplay between mechanical and biochemical signals in diseases like cancer and cardiovascular disease, and propose that a comprehensive mechanoochemical perspective is necessary for developing effective treatments.
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