2012 April 26; 366(17): 1567–1576. | Philip R. Schauer, M.D., Sangeeta R. Kashyap, M.D., Kathy Wolski, M.P.H., Stacy A. Brethauer, M.D., John P. Kirwan, Ph.D., Claire E. Pothier, M.P.H., Susan Thomas, R.N., Beth Abood, R.N., Steven E. Nissen, M.D., and Deepak L. Bhatt, M.D., M.P.H.
This randomized, nonblinded, single-center trial evaluated the efficacy of intensive medical therapy alone versus medical therapy plus Roux-en-Y gastric bypass or sleeve gastrectomy in 150 obese patients with uncontrolled type 2 diabetes. The primary endpoint was the proportion of patients with a glycated hemoglobin level of 6.0% or less 12 months after treatment. The results showed that 42% of patients in the gastric-bypass group and 37% in the sleeve-gastrectomy group achieved the primary endpoint, compared to only 12% in the medical-therapy group (P = 0.002 and P = 0.008, respectively). Glycemic control improved in all three groups, with significant reductions in glycated hemoglobin levels and fasting plasma glucose. Weight loss was greater in the gastric-bypass and sleeve-gastrectomy groups (−29.4 ± 9.0 kg and −25.1 ± 8.5 kg, respectively) compared to the medical-therapy group (−5.4 ± 8.0 kg). The use of glucose, lipid, and blood-pressure medications decreased significantly after both surgical procedures but increased in patients receiving medical therapy only. The study concluded that in obese patients with uncontrolled type 2 diabetes, 12 months of medical therapy plus bariatric surgery achieved glycemic control in significantly more patients than medical therapy alone. Further studies are needed to assess the long-term durability of these results.This randomized, nonblinded, single-center trial evaluated the efficacy of intensive medical therapy alone versus medical therapy plus Roux-en-Y gastric bypass or sleeve gastrectomy in 150 obese patients with uncontrolled type 2 diabetes. The primary endpoint was the proportion of patients with a glycated hemoglobin level of 6.0% or less 12 months after treatment. The results showed that 42% of patients in the gastric-bypass group and 37% in the sleeve-gastrectomy group achieved the primary endpoint, compared to only 12% in the medical-therapy group (P = 0.002 and P = 0.008, respectively). Glycemic control improved in all three groups, with significant reductions in glycated hemoglobin levels and fasting plasma glucose. Weight loss was greater in the gastric-bypass and sleeve-gastrectomy groups (−29.4 ± 9.0 kg and −25.1 ± 8.5 kg, respectively) compared to the medical-therapy group (−5.4 ± 8.0 kg). The use of glucose, lipid, and blood-pressure medications decreased significantly after both surgical procedures but increased in patients receiving medical therapy only. The study concluded that in obese patients with uncontrolled type 2 diabetes, 12 months of medical therapy plus bariatric surgery achieved glycemic control in significantly more patients than medical therapy alone. Further studies are needed to assess the long-term durability of these results.