The COVID-19 Resource Centre, established by Elsevier in January 2020, provides free information in English and Mandarin on the novel coronavirus. Elsevier grants permission to make all COVID-19-related research available in PubMed Central and other public repositories, with unrestricted reuse and analysis rights, as long as the resource centre remains active. The article discusses the role of clinicians in the context of the pandemic, emphasizing their responsibility as guardians of public health, medicine, and science. Clinicians must navigate a complex landscape of rapidly evolving scientific knowledge, partisan messaging, and the rapid spread of misinformation. They are tasked with protecting patients from both physical disease and the "disease of misinformation," which can undermine trust in healthcare and impede clinical and public health practices. The pandemic has highlighted the importance of digital technology in health management, with increased reliance on telemedicine and social media. However, this has also led to challenges in interpreting health information, with up to 50% of Americans encountering fake news online. Misinformation has complicated clinical care and vaccine acceptance, with significant implications for public health. To address these issues, clinicians need to engage more actively with patients, community groups, and social media to communicate evidence-based information and rebuild trust. They must also work with medical societies to promote a renewed commitment to science and dispel non-scientific mistruths. Clinicians are crucial in translating cutting-edge research into actionable treatment plans and supporting at-risk communities. Effective advocacy through social media remains vital, as it allows clinicians to reach a wide audience and highlight trusted resources. The article concludes by emphasizing the need for clinicians to step up and maintain their role as guardians of science and public trust.The COVID-19 Resource Centre, established by Elsevier in January 2020, provides free information in English and Mandarin on the novel coronavirus. Elsevier grants permission to make all COVID-19-related research available in PubMed Central and other public repositories, with unrestricted reuse and analysis rights, as long as the resource centre remains active. The article discusses the role of clinicians in the context of the pandemic, emphasizing their responsibility as guardians of public health, medicine, and science. Clinicians must navigate a complex landscape of rapidly evolving scientific knowledge, partisan messaging, and the rapid spread of misinformation. They are tasked with protecting patients from both physical disease and the "disease of misinformation," which can undermine trust in healthcare and impede clinical and public health practices. The pandemic has highlighted the importance of digital technology in health management, with increased reliance on telemedicine and social media. However, this has also led to challenges in interpreting health information, with up to 50% of Americans encountering fake news online. Misinformation has complicated clinical care and vaccine acceptance, with significant implications for public health. To address these issues, clinicians need to engage more actively with patients, community groups, and social media to communicate evidence-based information and rebuild trust. They must also work with medical societies to promote a renewed commitment to science and dispel non-scientific mistruths. Clinicians are crucial in translating cutting-edge research into actionable treatment plans and supporting at-risk communities. Effective advocacy through social media remains vital, as it allows clinicians to reach a wide audience and highlight trusted resources. The article concludes by emphasizing the need for clinicians to step up and maintain their role as guardians of science and public trust.