A novel bi-metallic, ferric oxide, and carbon nanotube-assisted surface plasmon resonance (SPR) sensor is proposed for cancer detection. The sensor utilizes the optoelectronic properties of ferric oxide (Fe₂O₃), carbon nanotubes (CNTs), and bi-metallic (silver and platinum) materials to enhance the sensitivity and performance of SPR-based cancer detection. The sensor's high sensitivity to minute variations in biomarker concentrations makes it useful for early cancer detection and monitoring. The refractive index (RI) of different malignant cells varied from 1.392 to 1.401, with MCF-7 cells showing the highest sensitivity of 320.571 deg/RIU. The sensor's performance metrics include a detection accuracy of 0.54 deg⁻¹, a figure of merit of 174.129 RIU⁻¹, and a full width half maximum of 1.841 deg. Cancer is a major global health issue, with over 10 million deaths in 2021. Early detection is crucial for effective treatment. The sensor can detect various cancers, including breast cancer (MCF-7), adrenal cancer (PC12), blood cancer (Jurkat), cervical cancer (HeLa), and skin cancer (basal). The refractive index of cancerous cells differs from that of healthy cells, making them detectable by the sensor. The sensor's high sensitivity allows for the detection of cancerous cells in pleural effusions, which are more reliable sources of breast cancer cells. SPR sensors are widely used due to their high sensitivity, speed, portability, and reliability. The sensor uses a prism-coupled Kretschmann configuration to enhance propagation properties. The sensor can detect folic acid protein (FAP) in cancer samples, making it suitable for clinical research. Noble metals like gold and silver are used to generate spontaneous photonic crystals. Doped materials exhibit plasmonic phenomena similar to two-dimensional materials, which can improve the performance of optoelectronic nanodevices. Platinum is used in SPR sensors due to its high reflecting properties, inertness, and chemical stability. The sensor's sensitivity increases with the rise in the sensing medium's RI. The introduction of 2D materials can improve sensitivity and absorption. Ferric oxide is used to increase sensitivity, but further research is needed. CNTs are also explored as a complement to biosensing principles. The sensor's performance is enhanced by the use of bi-metallic, ferric oxide, and carbon nanotube materials.A novel bi-metallic, ferric oxide, and carbon nanotube-assisted surface plasmon resonance (SPR) sensor is proposed for cancer detection. The sensor utilizes the optoelectronic properties of ferric oxide (Fe₂O₃), carbon nanotubes (CNTs), and bi-metallic (silver and platinum) materials to enhance the sensitivity and performance of SPR-based cancer detection. The sensor's high sensitivity to minute variations in biomarker concentrations makes it useful for early cancer detection and monitoring. The refractive index (RI) of different malignant cells varied from 1.392 to 1.401, with MCF-7 cells showing the highest sensitivity of 320.571 deg/RIU. The sensor's performance metrics include a detection accuracy of 0.54 deg⁻¹, a figure of merit of 174.129 RIU⁻¹, and a full width half maximum of 1.841 deg. Cancer is a major global health issue, with over 10 million deaths in 2021. Early detection is crucial for effective treatment. The sensor can detect various cancers, including breast cancer (MCF-7), adrenal cancer (PC12), blood cancer (Jurkat), cervical cancer (HeLa), and skin cancer (basal). The refractive index of cancerous cells differs from that of healthy cells, making them detectable by the sensor. The sensor's high sensitivity allows for the detection of cancerous cells in pleural effusions, which are more reliable sources of breast cancer cells. SPR sensors are widely used due to their high sensitivity, speed, portability, and reliability. The sensor uses a prism-coupled Kretschmann configuration to enhance propagation properties. The sensor can detect folic acid protein (FAP) in cancer samples, making it suitable for clinical research. Noble metals like gold and silver are used to generate spontaneous photonic crystals. Doped materials exhibit plasmonic phenomena similar to two-dimensional materials, which can improve the performance of optoelectronic nanodevices. Platinum is used in SPR sensors due to its high reflecting properties, inertness, and chemical stability. The sensor's sensitivity increases with the rise in the sensing medium's RI. The introduction of 2D materials can improve sensitivity and absorption. Ferric oxide is used to increase sensitivity, but further research is needed. CNTs are also explored as a complement to biosensing principles. The sensor's performance is enhanced by the use of bi-metallic, ferric oxide, and carbon nanotube materials.