The article reviews the applications of biaryl phosphine ligands in palladium-catalyzed amination reactions of aryl halides and pseudo-halides. These ligands have proven to be highly active catalysts in various reactions, including C-N cross-coupling in heterocycle synthesis, pharmaceuticals, materials science, and natural product synthesis. The review highlights the structural features of biaryl phosphine ligands, their synthesis, and the mechanisms behind their catalytic activity. It also discusses the use of these ligands in the synthesis of imines, enamines, and enamides, as well as in the construction of heterocycles. The article further explores the applications of these ligands in pharmaceutical synthesis, natural product synthesis, and the modification of biomolecules. Additionally, it covers process development, reaction conditions, solid-supported catalysts, and their use in the synthesis of ligands and sensors. The review concludes by discussing the future prospects and challenges in the field, emphasizing the increasing use of microwave heating and the need for better ligand design to achieve low catalyst loadings with substrates containing multiple heteroatoms.The article reviews the applications of biaryl phosphine ligands in palladium-catalyzed amination reactions of aryl halides and pseudo-halides. These ligands have proven to be highly active catalysts in various reactions, including C-N cross-coupling in heterocycle synthesis, pharmaceuticals, materials science, and natural product synthesis. The review highlights the structural features of biaryl phosphine ligands, their synthesis, and the mechanisms behind their catalytic activity. It also discusses the use of these ligands in the synthesis of imines, enamines, and enamides, as well as in the construction of heterocycles. The article further explores the applications of these ligands in pharmaceutical synthesis, natural product synthesis, and the modification of biomolecules. Additionally, it covers process development, reaction conditions, solid-supported catalysts, and their use in the synthesis of ligands and sensors. The review concludes by discussing the future prospects and challenges in the field, emphasizing the increasing use of microwave heating and the need for better ligand design to achieve low catalyst loadings with substrates containing multiple heteroatoms.