The article introduces a novel category of strain-engineered dynamic-shape materials, which can exhibit multi-dimensional shape modulations and form fine-grained adaptive microarchitectures. Using micro-origami tessellation technology, heterogeneous materials are equipped with strategic creases featuring stimuli-responsive micro-hinges that morph precisely upon chemical and electrical cues. The authors demonstrate three forms of these complex 4D metamaterials: freestanding multifaceted foldable packages, auxetic mesosurfaces, and morphable cages. These systems are integrated into two proof-of-concept bioelectronic demonstrations: a soft foldable supercapacitor that enhances power density to ∼108 mW cm−2, and a bio-adaptive device with a dynamic shape that may enable novel smart-implant technologies. The work showcases the potential of intelligent material systems to support ultra-flexible 4D microelectronics, which can endow devices with autonomy and realize microelectronic morphogenesis. The article also discusses the challenges and applications of these advanced materials in biomedical devices, such as adaptive smart tissues for aneurysm embolization, intelligent stents, and nerve regeneration scaffolds.The article introduces a novel category of strain-engineered dynamic-shape materials, which can exhibit multi-dimensional shape modulations and form fine-grained adaptive microarchitectures. Using micro-origami tessellation technology, heterogeneous materials are equipped with strategic creases featuring stimuli-responsive micro-hinges that morph precisely upon chemical and electrical cues. The authors demonstrate three forms of these complex 4D metamaterials: freestanding multifaceted foldable packages, auxetic mesosurfaces, and morphable cages. These systems are integrated into two proof-of-concept bioelectronic demonstrations: a soft foldable supercapacitor that enhances power density to ∼108 mW cm−2, and a bio-adaptive device with a dynamic shape that may enable novel smart-implant technologies. The work showcases the potential of intelligent material systems to support ultra-flexible 4D microelectronics, which can endow devices with autonomy and realize microelectronic morphogenesis. The article also discusses the challenges and applications of these advanced materials in biomedical devices, such as adaptive smart tissues for aneurysm embolization, intelligent stents, and nerve regeneration scaffolds.