This systematic review evaluates the potential of bioactive glass (BG)-based materials in promoting diabetic wound healing. Diabetic foot ulcers (DFUs) affect 15% of diabetic patients and are challenging to heal due to factors like neuropathy, arterial disease, and impaired extracellular matrix (ECM) degradation. BG-based materials show promise in accelerating wound healing by activating fibroblasts, enhancing M1-to-M2 macrophage switching, inducing angiogenesis, and promoting granulation tissue formation and re-epithelialization. In vitro and in vivo studies indicate that BG improves collagen deposition, wound healing quality, and angiogenesis. The review, following PRISMA guidelines, analyzed 19 studies, including in vitro and in vivo experiments, focusing on hydrogels, electrospun fibers, and scaffolds. BG-based materials demonstrated good cytocompatibility, antimicrobial properties, and enhanced angiogenesis. In vivo studies showed improved wound healing, reduced inflammation, and better collagen organization. BG also promoted macrophage polarization, aiding in the transition from inflammatory to proliferative phases of wound healing. Overall, BG-based materials show significant potential in improving diabetic wound healing, with promising results in accelerating healing and enhancing tissue regeneration.This systematic review evaluates the potential of bioactive glass (BG)-based materials in promoting diabetic wound healing. Diabetic foot ulcers (DFUs) affect 15% of diabetic patients and are challenging to heal due to factors like neuropathy, arterial disease, and impaired extracellular matrix (ECM) degradation. BG-based materials show promise in accelerating wound healing by activating fibroblasts, enhancing M1-to-M2 macrophage switching, inducing angiogenesis, and promoting granulation tissue formation and re-epithelialization. In vitro and in vivo studies indicate that BG improves collagen deposition, wound healing quality, and angiogenesis. The review, following PRISMA guidelines, analyzed 19 studies, including in vitro and in vivo experiments, focusing on hydrogels, electrospun fibers, and scaffolds. BG-based materials demonstrated good cytocompatibility, antimicrobial properties, and enhanced angiogenesis. In vivo studies showed improved wound healing, reduced inflammation, and better collagen organization. BG also promoted macrophage polarization, aiding in the transition from inflammatory to proliferative phases of wound healing. Overall, BG-based materials show significant potential in improving diabetic wound healing, with promising results in accelerating healing and enhancing tissue regeneration.