Bioactive glass and glass-ceramic scaffolds are promising materials for bone tissue engineering due to their ability to interact with biological systems and promote bone regeneration. This review discusses the development and properties of these scaffolds, highlighting their potential in bone tissue engineering. Bioactive glasses, such as 45S5 Bioglass, have been shown to form strong bonds with bone through the formation of hydroxyapatite layers, leading to effective biological interaction and fixation. The release of ions from bioactive glasses can stimulate osteogenic and angiogenic responses, enhancing bone formation. Recent studies have demonstrated that bioactive glass-ceramic scaffolds can exhibit mechanical properties comparable to cancellous bone and close to cortical bone, making them suitable for load-bearing applications. The mechanical properties of these scaffolds are influenced by factors such as porosity, pore structure, and interconnectivity. Compressive strength and elastic modulus values of bioactive glass-ceramic scaffolds have been found to be in the range of cancellous bone, with some scaffolds exhibiting values close to cortical bone. The development of composite scaffolds incorporating bioactive glass with biodegradable polymers has shown promise in improving mechanical properties and promoting bone regeneration. These composites can be tailored to have specific mechanical and biological properties, making them suitable for various bone tissue engineering applications. The review also highlights the importance of scaffold design in achieving optimal mechanical and biological performance, emphasizing the need for a balance between porosity and mechanical strength. Overall, bioactive glass and glass-ceramic scaffolds represent a significant advancement in bone tissue engineering, offering potential solutions for bone repair and regeneration.Bioactive glass and glass-ceramic scaffolds are promising materials for bone tissue engineering due to their ability to interact with biological systems and promote bone regeneration. This review discusses the development and properties of these scaffolds, highlighting their potential in bone tissue engineering. Bioactive glasses, such as 45S5 Bioglass, have been shown to form strong bonds with bone through the formation of hydroxyapatite layers, leading to effective biological interaction and fixation. The release of ions from bioactive glasses can stimulate osteogenic and angiogenic responses, enhancing bone formation. Recent studies have demonstrated that bioactive glass-ceramic scaffolds can exhibit mechanical properties comparable to cancellous bone and close to cortical bone, making them suitable for load-bearing applications. The mechanical properties of these scaffolds are influenced by factors such as porosity, pore structure, and interconnectivity. Compressive strength and elastic modulus values of bioactive glass-ceramic scaffolds have been found to be in the range of cancellous bone, with some scaffolds exhibiting values close to cortical bone. The development of composite scaffolds incorporating bioactive glass with biodegradable polymers has shown promise in improving mechanical properties and promoting bone regeneration. These composites can be tailored to have specific mechanical and biological properties, making them suitable for various bone tissue engineering applications. The review also highlights the importance of scaffold design in achieving optimal mechanical and biological performance, emphasizing the need for a balance between porosity and mechanical strength. Overall, bioactive glass and glass-ceramic scaffolds represent a significant advancement in bone tissue engineering, offering potential solutions for bone repair and regeneration.