This review discusses recent advancements in the use of bioactive glass for tissue engineering applications. Despite its brittleness, bioactive glass is appealing as a scaffold material for bone tissue engineering. New bioactive glasses based on borate and borosilicate compositions have shown the ability to enhance new bone formation compared to silicate bioactive glass. Borate-based bioactive glasses have controllable degradation rates, allowing the degradation of the implant to match the rate of new bone formation. Bioactive glasses can be doped with elements like Cu, Zn, and Sr, which are beneficial for bone growth. Recent advances in biomaterials processing have led to the creation of scaffolds with a range of mechanical properties suitable for both loaded and non-loaded bone. While bioactive glass has been extensively studied for bone repair, there is relatively little research on its application to soft tissue repair. However, recent work has shown that bioactive glass can promote angiogenesis, which is critical for tissue regeneration. Bioactive glass has also been shown to enhance neocartilage formation and serve as a subchondral substrate for tissue-engineered osteochondral constructs. Methods used to manipulate the structure and performance of bioactive glass in these applications are analyzed. Keywords include bioactive glass, tissue engineering, scaffolds, bone repair, angiogenesis, soft tissue repair, chondrogenesis, and osteochondral tissues. The review highlights the role of bioactive glass in tissue engineering, focusing on recent developments of new bioactive glasses and their conversion into scaffolds with the required anatomical shape and architecture. Methods to manipulate the materials structure and variables affecting performance are analyzed. The review discusses the properties of bioactive glass, including its bioactivity, which is defined as the ability to induce specific biological activity. Bioactive glass forms an HA-like layer when immersed in a simulated body fluid, indicating its bioactivity. The review also discusses the mechanisms of bioactivity and bone bonding of 45S5 glass, which form a carbonate-substituted hydroxyapatite-like (HCA) layer on the glass surface. The biological mechanisms of bonding to bone involve adsorption of growth factors, followed by attachment, proliferation, and differentiation of osteoprogenitor cells. The biocompatibility of 45S5 glass has been established, and it undergoes chemical degradation, releasing ions and converting to an HCA material. However, 45S5 glass has limitations as a scaffold material, including difficulty in processing into porous 3-D scaffolds and a slow degradation rate. A silicate bioactive glass designated 13–93 has better processing characteristics and degrades more slowly than 45S5 glass. Borate bioactive glass has been shown to support cell proliferation and differentiation in vitro and tissue infiltration in vivo. Borate bioactive glass can serve as a substrate for drug release in the treatment of bone infection. However, boron released into the solution can be toxicThis review discusses recent advancements in the use of bioactive glass for tissue engineering applications. Despite its brittleness, bioactive glass is appealing as a scaffold material for bone tissue engineering. New bioactive glasses based on borate and borosilicate compositions have shown the ability to enhance new bone formation compared to silicate bioactive glass. Borate-based bioactive glasses have controllable degradation rates, allowing the degradation of the implant to match the rate of new bone formation. Bioactive glasses can be doped with elements like Cu, Zn, and Sr, which are beneficial for bone growth. Recent advances in biomaterials processing have led to the creation of scaffolds with a range of mechanical properties suitable for both loaded and non-loaded bone. While bioactive glass has been extensively studied for bone repair, there is relatively little research on its application to soft tissue repair. However, recent work has shown that bioactive glass can promote angiogenesis, which is critical for tissue regeneration. Bioactive glass has also been shown to enhance neocartilage formation and serve as a subchondral substrate for tissue-engineered osteochondral constructs. Methods used to manipulate the structure and performance of bioactive glass in these applications are analyzed. Keywords include bioactive glass, tissue engineering, scaffolds, bone repair, angiogenesis, soft tissue repair, chondrogenesis, and osteochondral tissues. The review highlights the role of bioactive glass in tissue engineering, focusing on recent developments of new bioactive glasses and their conversion into scaffolds with the required anatomical shape and architecture. Methods to manipulate the materials structure and variables affecting performance are analyzed. The review discusses the properties of bioactive glass, including its bioactivity, which is defined as the ability to induce specific biological activity. Bioactive glass forms an HA-like layer when immersed in a simulated body fluid, indicating its bioactivity. The review also discusses the mechanisms of bioactivity and bone bonding of 45S5 glass, which form a carbonate-substituted hydroxyapatite-like (HCA) layer on the glass surface. The biological mechanisms of bonding to bone involve adsorption of growth factors, followed by attachment, proliferation, and differentiation of osteoprogenitor cells. The biocompatibility of 45S5 glass has been established, and it undergoes chemical degradation, releasing ions and converting to an HCA material. However, 45S5 glass has limitations as a scaffold material, including difficulty in processing into porous 3-D scaffolds and a slow degradation rate. A silicate bioactive glass designated 13–93 has better processing characteristics and degrades more slowly than 45S5 glass. Borate bioactive glass has been shown to support cell proliferation and differentiation in vitro and tissue infiltration in vivo. Borate bioactive glass can serve as a substrate for drug release in the treatment of bone infection. However, boron released into the solution can be toxic