This review focuses on recent advancements in the development and application of bioactive glass for tissue engineering. Despite its brittleness, bioactive glass exhibits several appealing characteristics as a scaffold material for bone tissue engineering. New bioactive glasses based on borate and borosilicate compositions have shown enhanced new bone formation compared to silicate bioactive glass. Borate-based bioactive glasses also offer controllable degradation rates, allowing the degradation rate to match the rate of new bone formation. These glasses can be doped with trace elements like Cu, Zn, and Sr, which are beneficial for healthy bone growth. In addition to bone repair, recent studies have shown that bioactive glass can promote angiogenesis, which is crucial for various tissue regeneration applications, such as neovascularization for bone regeneration and the healing of soft tissue wounds. Bioactive glass has also been shown to enhance neocartilage formation during in vitro culture of chondrocyte-seeded hydrogels and serve as a subchondral substrate for tissue-engineered osteochondral constructs. The review analyzes methods to manipulate the structure and performance of bioactive glass in these tissue engineering applications, including the use of electrospinning, solid freeform fabrication, and unidirectional freezing of suspensions. It also discusses the osteoconductivity and osteoinductivity of bioactive glass, its mechanical properties, and its response to cells. The in vitro and in vivo characteristics of bioactive glass scaffolds are evaluated, highlighting their potential for bone regeneration and soft tissue repair.This review focuses on recent advancements in the development and application of bioactive glass for tissue engineering. Despite its brittleness, bioactive glass exhibits several appealing characteristics as a scaffold material for bone tissue engineering. New bioactive glasses based on borate and borosilicate compositions have shown enhanced new bone formation compared to silicate bioactive glass. Borate-based bioactive glasses also offer controllable degradation rates, allowing the degradation rate to match the rate of new bone formation. These glasses can be doped with trace elements like Cu, Zn, and Sr, which are beneficial for healthy bone growth. In addition to bone repair, recent studies have shown that bioactive glass can promote angiogenesis, which is crucial for various tissue regeneration applications, such as neovascularization for bone regeneration and the healing of soft tissue wounds. Bioactive glass has also been shown to enhance neocartilage formation during in vitro culture of chondrocyte-seeded hydrogels and serve as a subchondral substrate for tissue-engineered osteochondral constructs. The review analyzes methods to manipulate the structure and performance of bioactive glass in these tissue engineering applications, including the use of electrospinning, solid freeform fabrication, and unidirectional freezing of suspensions. It also discusses the osteoconductivity and osteoinductivity of bioactive glass, its mechanical properties, and its response to cells. The in vitro and in vivo characteristics of bioactive glass scaffolds are evaluated, highlighting their potential for bone regeneration and soft tissue repair.