This methodological study examines the consideration of bioavailability in systematic reviews of oral curcumin. Curcumin, a compound found in turmeric, has shown promising biological activities but is limited by its poor bioavailability. The study analyzed 171 systematic reviews published between 2003 and 2022 to assess whether these reviews adequately addressed the bioavailability of curcumin formulations. Key findings include: - Only 9.3% of reviews mentioned bioavailability in their methods, 24% in their results, 57% in their discussion, and 13% in their conclusions. - Statistical subgroup and sensitivity analyses were reported in only 3.5% and 6.4% of reviews, respectively. - Most reviews (70%) mentioned funding sources, with most being non-commercial. - Many reviews used vague descriptions of interventions, and some included studies with different curcumin preparations. - Despite awareness of bioavailability issues, most reviews provided general comments rather than detailed analysis. The study concludes that systematic reviews often fail to adequately address the variable bioavailability of curcumin formulations, which can lead to misleading conclusions. Future systematic reviews should be more rigorous in their methods to ensure reliable recommendations for clinical use.This methodological study examines the consideration of bioavailability in systematic reviews of oral curcumin. Curcumin, a compound found in turmeric, has shown promising biological activities but is limited by its poor bioavailability. The study analyzed 171 systematic reviews published between 2003 and 2022 to assess whether these reviews adequately addressed the bioavailability of curcumin formulations. Key findings include: - Only 9.3% of reviews mentioned bioavailability in their methods, 24% in their results, 57% in their discussion, and 13% in their conclusions. - Statistical subgroup and sensitivity analyses were reported in only 3.5% and 6.4% of reviews, respectively. - Most reviews (70%) mentioned funding sources, with most being non-commercial. - Many reviews used vague descriptions of interventions, and some included studies with different curcumin preparations. - Despite awareness of bioavailability issues, most reviews provided general comments rather than detailed analysis. The study concludes that systematic reviews often fail to adequately address the variable bioavailability of curcumin formulations, which can lead to misleading conclusions. Future systematic reviews should be more rigorous in their methods to ensure reliable recommendations for clinical use.