This systematic review evaluates the biocompatibility of 3D-printed dental resins, a critical concern in modern dentistry due to the increasing use of additive manufacturing (AM) techniques. The review aims to provide insights into the potential biological risks associated with these materials to ensure patient safety and treatment efficacy. A comprehensive search across multiple databases identified 9 studies that met the inclusion criteria. These studies assessed various aspects of biocompatibility, including material composition, mechanical properties, cell viability, and cytotoxicity. Some resins showed significant improvements in flexural strength and cell viability, while others exhibited cytotoxicity. The review highlights that material composition, post-processing techniques, and manufacturing methods are critical factors influencing biocompatibility outcomes. While some resins demonstrated favorable biocompatibility, others raised concerns due to cytotoxicity. The findings emphasize the need for careful selection and comprehensive biocompatibility testing of 3D-printed dental resins. Further research is warranted to elucidate the long-term biocompatibility and clinical implications of these materials.This systematic review evaluates the biocompatibility of 3D-printed dental resins, a critical concern in modern dentistry due to the increasing use of additive manufacturing (AM) techniques. The review aims to provide insights into the potential biological risks associated with these materials to ensure patient safety and treatment efficacy. A comprehensive search across multiple databases identified 9 studies that met the inclusion criteria. These studies assessed various aspects of biocompatibility, including material composition, mechanical properties, cell viability, and cytotoxicity. Some resins showed significant improvements in flexural strength and cell viability, while others exhibited cytotoxicity. The review highlights that material composition, post-processing techniques, and manufacturing methods are critical factors influencing biocompatibility outcomes. While some resins demonstrated favorable biocompatibility, others raised concerns due to cytotoxicity. The findings emphasize the need for careful selection and comprehensive biocompatibility testing of 3D-printed dental resins. Further research is warranted to elucidate the long-term biocompatibility and clinical implications of these materials.