This systematic review evaluates the biocompatibility of 3D-printed dental resins, focusing on their safety, mechanical properties, and biological responses. A total of nine studies were included in the review, covering various aspects of biocompatibility, including material composition, mechanical strength, cell viability, and cytotoxicity. The findings indicate that certain resin formulations show improved mechanical properties and cell viability, while others exhibit cytotoxicity. Factors such as material composition, post-processing techniques, and manufacturing methods significantly influence biocompatibility outcomes. The review emphasizes the need for careful selection of materials and thorough biocompatibility testing to ensure patient safety and clinical effectiveness. While some resins demonstrate favorable biocompatibility profiles, others raise concerns due to cytotoxicity. The study highlights the importance of standardization in resin formulations and 3D printing processes to facilitate meaningful comparisons across studies. Additionally, the review notes the need for further research to explore the long-term biocompatibility and clinical implications of these materials. The findings underscore the critical role of material selection and processing in achieving desired clinical outcomes. Overall, the review provides valuable insights into the biocompatibility of 3D-printed dental resins, emphasizing the importance of material engineering and comprehensive testing in their application.This systematic review evaluates the biocompatibility of 3D-printed dental resins, focusing on their safety, mechanical properties, and biological responses. A total of nine studies were included in the review, covering various aspects of biocompatibility, including material composition, mechanical strength, cell viability, and cytotoxicity. The findings indicate that certain resin formulations show improved mechanical properties and cell viability, while others exhibit cytotoxicity. Factors such as material composition, post-processing techniques, and manufacturing methods significantly influence biocompatibility outcomes. The review emphasizes the need for careful selection of materials and thorough biocompatibility testing to ensure patient safety and clinical effectiveness. While some resins demonstrate favorable biocompatibility profiles, others raise concerns due to cytotoxicity. The study highlights the importance of standardization in resin formulations and 3D printing processes to facilitate meaningful comparisons across studies. Additionally, the review notes the need for further research to explore the long-term biocompatibility and clinical implications of these materials. The findings underscore the critical role of material selection and processing in achieving desired clinical outcomes. Overall, the review provides valuable insights into the biocompatibility of 3D-printed dental resins, emphasizing the importance of material engineering and comprehensive testing in their application.