This study introduces a biodegradable, biocompatible, and multifunctional nanosensor platform for cardiac monitoring. The platform integrates two electrochemical biosensors for detecting lactic acid and pH levels, a pressure sensor, and a chemiresistor array for volatile organic compound (VOC) detection. The sensors were fabricated using biodegradable materials such as poly(lactic acid) (PLA) and magnesium (Mg), and tested in vitro and ex vivo using 3D-printed heart models and cardiac tissue patches. The sensors demonstrated good biocompatibility and biodegradability, with minimal impact on cell viability. An artificial intelligence (AI)-based predictive model was developed to fuse sensor data, providing a comprehensive "health barcode" for precise health assessment. The platform's flexibility, ease of fabrication, and ability to detect multiple biomarkers make it a promising candidate for clinical use, offering advanced cardiac monitoring and management. The study highlights the potential of this platform in reducing the need for complex surgeries and improving patient outcomes.This study introduces a biodegradable, biocompatible, and multifunctional nanosensor platform for cardiac monitoring. The platform integrates two electrochemical biosensors for detecting lactic acid and pH levels, a pressure sensor, and a chemiresistor array for volatile organic compound (VOC) detection. The sensors were fabricated using biodegradable materials such as poly(lactic acid) (PLA) and magnesium (Mg), and tested in vitro and ex vivo using 3D-printed heart models and cardiac tissue patches. The sensors demonstrated good biocompatibility and biodegradability, with minimal impact on cell viability. An artificial intelligence (AI)-based predictive model was developed to fuse sensor data, providing a comprehensive "health barcode" for precise health assessment. The platform's flexibility, ease of fabrication, and ability to detect multiple biomarkers make it a promising candidate for clinical use, offering advanced cardiac monitoring and management. The study highlights the potential of this platform in reducing the need for complex surgeries and improving patient outcomes.