Biodegradable Natural Hydrogels for Tissue Engineering, Controlled Release, and Soil Remediation

Biodegradable Natural Hydrogels for Tissue Engineering, Controlled Release, and Soil Remediation

14 September 2024 | Ane Garcia-Garcia, Sara Muñana-González, Senentxu Lanceros-Mendez, Leire Ruiz-Rubio, Leyre Perez Alvarez, José Luis Vilas-Vilela
This article provides an overview of biodegradable natural hydrogels and their applications in tissue engineering, controlled release, and soil remediation. Hydrogels, composed of crosslinked polymer networks, are highly absorbent and retain large amounts of water, making them versatile materials with unique properties. The article highlights the advancements in degradable hydrogels, emphasizing their tunable degradation rates and biocompatibility. Natural polymers, such as polysaccharides (starch, cellulose, chitosan, alginate) and polypeptides (gelatin), are preferred for their sustainability, biocompatibility, and non-toxic degradation products. The degradation mechanisms of hydrogels, including hydrolysis, solubilization, oxidation, photodegradation, and enzymatic degradation, are discussed in detail. The article also reviews the degradation of specific natural polymers, such as starch, cellulose, chitosan, alginate, and gelatin, and their applications in various fields. Additionally, the article explores the use of biodegradable hydrogels in tissue engineering, where they serve as scaffolds for cell growth and tissue regeneration, and in controlled release systems for biomedical applications. The potential of these materials in sustainable agriculture and soil treatment is also highlighted, emphasizing their ability to mimic natural tissues and provide controlled release of nutrients and agrochemicals. Overall, the article underscores the importance of biodegradable hydrogels in addressing the challenges of tissue engineering, controlled release, and environmental sustainability.This article provides an overview of biodegradable natural hydrogels and their applications in tissue engineering, controlled release, and soil remediation. Hydrogels, composed of crosslinked polymer networks, are highly absorbent and retain large amounts of water, making them versatile materials with unique properties. The article highlights the advancements in degradable hydrogels, emphasizing their tunable degradation rates and biocompatibility. Natural polymers, such as polysaccharides (starch, cellulose, chitosan, alginate) and polypeptides (gelatin), are preferred for their sustainability, biocompatibility, and non-toxic degradation products. The degradation mechanisms of hydrogels, including hydrolysis, solubilization, oxidation, photodegradation, and enzymatic degradation, are discussed in detail. The article also reviews the degradation of specific natural polymers, such as starch, cellulose, chitosan, alginate, and gelatin, and their applications in various fields. Additionally, the article explores the use of biodegradable hydrogels in tissue engineering, where they serve as scaffolds for cell growth and tissue regeneration, and in controlled release systems for biomedical applications. The potential of these materials in sustainable agriculture and soil treatment is also highlighted, emphasizing their ability to mimic natural tissues and provide controlled release of nutrients and agrochemicals. Overall, the article underscores the importance of biodegradable hydrogels in addressing the challenges of tissue engineering, controlled release, and environmental sustainability.
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