This study presents the development of biodegradable starch-based nanocomposite films reinforced with MXene nanoplatelets, which significantly enhance the mechanical properties and barrier performance of starch films. By incorporating 10 wt % MXene into starch films, the Young's modulus increased from 456 MPa to 1923 MPa, and the tensile strength increased from 10 MPa to 19 MPa. The films also showed a dramatic reduction in water vapor permeability (92.9%) and oxygen permeability (74.0%), making them highly effective as moisture and gas barriers. These improvements are attributed to the strong interfacial interactions between MXene and starch, which enhance mechanical strength and create a more compact structure that reduces permeability. The films retained their biodegradability, decomposing completely in soil within 6 weeks, demonstrating their environmental friendliness. The study highlights the potential of MXene nanoplatelets to enhance the performance of biopolymers while maintaining their biodegradability, offering a sustainable alternative to conventional plastics. The results show that starch/MXene nanocomposite films have excellent mechanical properties, moisture resistance, and barrier performance, making them suitable for various applications, including packaging. The findings suggest that MXene-based nanocomposites could be a promising solution for developing sustainable, high-performance materials.This study presents the development of biodegradable starch-based nanocomposite films reinforced with MXene nanoplatelets, which significantly enhance the mechanical properties and barrier performance of starch films. By incorporating 10 wt % MXene into starch films, the Young's modulus increased from 456 MPa to 1923 MPa, and the tensile strength increased from 10 MPa to 19 MPa. The films also showed a dramatic reduction in water vapor permeability (92.9%) and oxygen permeability (74.0%), making them highly effective as moisture and gas barriers. These improvements are attributed to the strong interfacial interactions between MXene and starch, which enhance mechanical strength and create a more compact structure that reduces permeability. The films retained their biodegradability, decomposing completely in soil within 6 weeks, demonstrating their environmental friendliness. The study highlights the potential of MXene nanoplatelets to enhance the performance of biopolymers while maintaining their biodegradability, offering a sustainable alternative to conventional plastics. The results show that starch/MXene nanocomposite films have excellent mechanical properties, moisture resistance, and barrier performance, making them suitable for various applications, including packaging. The findings suggest that MXene-based nanocomposites could be a promising solution for developing sustainable, high-performance materials.