This study presents bioinspired directional structures (BDSs) fabricated on Y₂O₃-stabilized ZrO₂ (YSZ) surfaces using femtosecond laser ablation to inhibit wetting by high-temperature molten CaO–MgO–Al₂O₃–SiO₂ (CMAS) droplets at temperatures above 1200 °C. The BDSs, designed with anisotropic energy barriers, significantly increased the contact angle (CA) of CMAS from 9.2° to 60° at 1250 °C and reduced the spreading area (SA) by 70.1%. At 1400 °C, the CA increased from 3.3° to 31.3°, and the SA decreased by 67.9%. These results demonstrate that the BDSs effectively inhibit wetting of CMAS on super-CMAS-melt-philic YSZ surfaces without the need for additional chemical modifiers. The study also shows that the wetting inhibition property of the BDSs remains stable even after prolonged heating and high temperatures. The mechanism of wetting inhibition is attributed to the anisotropic energy barriers created by the directional structures, which hinder the movement of molten CMAS in certain directions. The results suggest that the BDSs provide a promising strategy for inhibiting the wetting of molten droplets on super-melt-philic surfaces at extremely high temperatures.This study presents bioinspired directional structures (BDSs) fabricated on Y₂O₃-stabilized ZrO₂ (YSZ) surfaces using femtosecond laser ablation to inhibit wetting by high-temperature molten CaO–MgO–Al₂O₃–SiO₂ (CMAS) droplets at temperatures above 1200 °C. The BDSs, designed with anisotropic energy barriers, significantly increased the contact angle (CA) of CMAS from 9.2° to 60° at 1250 °C and reduced the spreading area (SA) by 70.1%. At 1400 °C, the CA increased from 3.3° to 31.3°, and the SA decreased by 67.9%. These results demonstrate that the BDSs effectively inhibit wetting of CMAS on super-CMAS-melt-philic YSZ surfaces without the need for additional chemical modifiers. The study also shows that the wetting inhibition property of the BDSs remains stable even after prolonged heating and high temperatures. The mechanism of wetting inhibition is attributed to the anisotropic energy barriers created by the directional structures, which hinder the movement of molten CMAS in certain directions. The results suggest that the BDSs provide a promising strategy for inhibiting the wetting of molten droplets on super-melt-philic surfaces at extremely high temperatures.