This study investigates the development of bioinspired directional structures (BDSs) on Y2O3-stabilized ZrO2 (YSZ) surfaces to inhibit the wetting of high-temperature molten droplets (above 1200 °C). The BDSs were fabricated using femtosecond laser ablation, inspired by the anisotropic wettability of rice leaves. The BDSs exhibited significant improvements in contact angle (CA) and reduction in spreading area (SA) compared to polished super-CMAS-melt-philic YSZ surfaces. At 1250 °C, the BDSs increased the CA from 9.2° to 60° and reduced the SA by 70.1%. Even at 1400 °C, the BDSs increased the CA from 3.3° to 31.3° and reduced the SA by 67.9%. The enhanced wetting inhibition was attributed to the anisotropic energy barriers provided by the BDSs, which hindered the movement of the three-phase contact line (TCL) perpendicular to the grooves. The robustness of the BDSs was further demonstrated through long-term heating and high-temperature treatments, showing minimal degradation in their wetting inhibition properties. This work provides a valuable strategy for effectively inhibiting the wetting of molten droplets on super-melt-philic surfaces at extremely high temperatures.This study investigates the development of bioinspired directional structures (BDSs) on Y2O3-stabilized ZrO2 (YSZ) surfaces to inhibit the wetting of high-temperature molten droplets (above 1200 °C). The BDSs were fabricated using femtosecond laser ablation, inspired by the anisotropic wettability of rice leaves. The BDSs exhibited significant improvements in contact angle (CA) and reduction in spreading area (SA) compared to polished super-CMAS-melt-philic YSZ surfaces. At 1250 °C, the BDSs increased the CA from 9.2° to 60° and reduced the SA by 70.1%. Even at 1400 °C, the BDSs increased the CA from 3.3° to 31.3° and reduced the SA by 67.9%. The enhanced wetting inhibition was attributed to the anisotropic energy barriers provided by the BDSs, which hindered the movement of the three-phase contact line (TCL) perpendicular to the grooves. The robustness of the BDSs was further demonstrated through long-term heating and high-temperature treatments, showing minimal degradation in their wetting inhibition properties. This work provides a valuable strategy for effectively inhibiting the wetting of molten droplets on super-melt-philic surfaces at extremely high temperatures.