Biological, Epidemiological, and Clinical Aspects of Echinococcosis, a Zoonosis of Increasing Concern

Biological, Epidemiological, and Clinical Aspects of Echinococcosis, a Zoonosis of Increasing Concern

Jan. 2004 | Johannes Eckert* and Peter Deplazes
Echinococcosis is a zoonotic disease caused by cestodes of the genus Echinococcus. The life cycle involves two mammalian hosts: definitive hosts (e.g., dogs) and intermediate hosts (e.g., sheep, goats). Eggs are excreted by definitive hosts and ingested by intermediate hosts, where they develop into metacestodes. These can cause severe disease in intermediate or aberrant hosts. Two main forms of echinococcosis in humans are cystic echinococcosis (CE) and alveolar echinococcosis (AE), with CE being more widespread and economically significant. Polycystic echinococcosis is less common and restricted to Central and South America. CE is caused by E. granulosus and involves the development of cysts in organs like the liver and lungs. Diagnosis is based on imaging and serological tests. Treatment options include surgery, PAIR (puncture-aspiration-injection-reaspiration), and chemotherapy. AE, caused by E. multilocularis, is more aggressive and requires surgery or chemotherapy. E. multilocularis is found in Arctic and sub-Arctic regions, with transmission influenced by rodent populations and foxes. E. granulosus has several strains, with the sheep strain being the most common cause of human CE. Other strains, such as the camel and horse strains, are less common. The life cycle of E. granulosus involves dogs as definitive hosts and various ungulates as intermediate hosts. Transmission is influenced by environmental factors, human behavior, and animal husbandry practices. Echinococcosis is prevalent in many regions, with high incidence in parts of Eurasia, Africa, Australia, and South America. Factors contributing to the persistence, emergence, or reemergence of the disease include the presence of stray dogs, poor sanitation, and economic instability. Control measures include public health education, vaccination of intermediate hosts, and the use of praziquantel for treating infected dogs. Prevention and control strategies involve improving sanitation, controlling stray dog populations, and implementing vaccination programs. Research is ongoing to develop effective vaccines and improve diagnostic methods. Despite these efforts, echinococcosis remains a significant public health challenge, particularly in regions with limited resources and poor infrastructure.Echinococcosis is a zoonotic disease caused by cestodes of the genus Echinococcus. The life cycle involves two mammalian hosts: definitive hosts (e.g., dogs) and intermediate hosts (e.g., sheep, goats). Eggs are excreted by definitive hosts and ingested by intermediate hosts, where they develop into metacestodes. These can cause severe disease in intermediate or aberrant hosts. Two main forms of echinococcosis in humans are cystic echinococcosis (CE) and alveolar echinococcosis (AE), with CE being more widespread and economically significant. Polycystic echinococcosis is less common and restricted to Central and South America. CE is caused by E. granulosus and involves the development of cysts in organs like the liver and lungs. Diagnosis is based on imaging and serological tests. Treatment options include surgery, PAIR (puncture-aspiration-injection-reaspiration), and chemotherapy. AE, caused by E. multilocularis, is more aggressive and requires surgery or chemotherapy. E. multilocularis is found in Arctic and sub-Arctic regions, with transmission influenced by rodent populations and foxes. E. granulosus has several strains, with the sheep strain being the most common cause of human CE. Other strains, such as the camel and horse strains, are less common. The life cycle of E. granulosus involves dogs as definitive hosts and various ungulates as intermediate hosts. Transmission is influenced by environmental factors, human behavior, and animal husbandry practices. Echinococcosis is prevalent in many regions, with high incidence in parts of Eurasia, Africa, Australia, and South America. Factors contributing to the persistence, emergence, or reemergence of the disease include the presence of stray dogs, poor sanitation, and economic instability. Control measures include public health education, vaccination of intermediate hosts, and the use of praziquantel for treating infected dogs. Prevention and control strategies involve improving sanitation, controlling stray dog populations, and implementing vaccination programs. Research is ongoing to develop effective vaccines and improve diagnostic methods. Despite these efforts, echinococcosis remains a significant public health challenge, particularly in regions with limited resources and poor infrastructure.
Reach us at info@study.space