The article reviews the biological activities of polyphenols from grapes, which are associated with a reduced incidence of degenerative diseases such as cardiovascular disease and certain types of cancer. The most important grape polyphenols include anthocyanins, flavanols, flavonols, and resveratrol, which possess various biological activities such as antioxidant, cardioprotective, anticancer, anti-inflammatory, anti-aging, and antimicrobial properties. The review covers the extraction, isolation, and identification methods of polyphenols from grapes, their bioavailability, and potential toxicity. It highlights the significant health benefits of grape polyphenols, including their ability to reduce oxidative stress, protect against cardiovascular diseases, inhibit cancer cell growth, reduce inflammation, delay aging, and prevent microbial infections. The article also discusses the structure-activity relationships of some polyphenols and suggests future research directions to further explore the potential of grape polyphenols in food and pharmaceutical applications.The article reviews the biological activities of polyphenols from grapes, which are associated with a reduced incidence of degenerative diseases such as cardiovascular disease and certain types of cancer. The most important grape polyphenols include anthocyanins, flavanols, flavonols, and resveratrol, which possess various biological activities such as antioxidant, cardioprotective, anticancer, anti-inflammatory, anti-aging, and antimicrobial properties. The review covers the extraction, isolation, and identification methods of polyphenols from grapes, their bioavailability, and potential toxicity. It highlights the significant health benefits of grape polyphenols, including their ability to reduce oxidative stress, protect against cardiovascular diseases, inhibit cancer cell growth, reduce inflammation, delay aging, and prevent microbial infections. The article also discusses the structure-activity relationships of some polyphenols and suggests future research directions to further explore the potential of grape polyphenols in food and pharmaceutical applications.