This study reports the results of a multi-stage genome-wide association study (GWAS) of schizophrenia, involving up to 36,989 cases and 113,075 controls. The analysis identified 128 independent associations spanning 108 loci, 83 of which were previously unreported. These associations were enriched among genes expressed in the brain, providing biological plausibility for the findings. Many of the associations highlight molecules of known and potential therapeutic relevance to schizophrenia, such as *DRD2* and genes involved in glutamatergic neurotransmission. Additionally, associations at *CACNA1C*, *CACNB2*, and *CACNA1I* extend previous findings implicating calcium channel subunits in schizophrenia. The study also found that associations were enriched among genes expressed in tissues with important roles in immunity, supporting the speculative link between the immune system and schizophrenia. The findings suggest that common genetic variants contribute significantly to the heritability of schizophrenia and provide new insights into its aetiology and potential therapeutic targets.This study reports the results of a multi-stage genome-wide association study (GWAS) of schizophrenia, involving up to 36,989 cases and 113,075 controls. The analysis identified 128 independent associations spanning 108 loci, 83 of which were previously unreported. These associations were enriched among genes expressed in the brain, providing biological plausibility for the findings. Many of the associations highlight molecules of known and potential therapeutic relevance to schizophrenia, such as *DRD2* and genes involved in glutamatergic neurotransmission. Additionally, associations at *CACNA1C*, *CACNB2*, and *CACNA1I* extend previous findings implicating calcium channel subunits in schizophrenia. The study also found that associations were enriched among genes expressed in tissues with important roles in immunity, supporting the speculative link between the immune system and schizophrenia. The findings suggest that common genetic variants contribute significantly to the heritability of schizophrenia and provide new insights into its aetiology and potential therapeutic targets.