This review summarizes the biological activities of hydrazones, a class of compounds with diverse therapeutic potential. Hydrazones, containing an azometine group, have been extensively studied for their anticonvulsant, antidepressant, analgesic, anti-inflammatory, antimalarial, antimicrobial, antimycobacterial, antitumoral, vasodilator, and antiviral properties. The review highlights the synthesis and evaluation of various hydrazones, emphasizing their biological activities against pathogens and cancer cells. Key findings include the antitubercular activity of isoniazid derivatives, the antimicrobial effects of certain hydrazones against bacteria and fungi, and the antitumoral activity of several hydrazones. Additionally, the review discusses the antiviral activity of some hydrazones against viruses such as HIV and the vasodilator effects of certain compounds. The study also covers the antimycobacterial activity of various hydrazones, including their effectiveness against drug-resistant strains of Mycobacterium tuberculosis. The review concludes with a critical evaluation of the pharmacological activity of hydrazones over the past decade, highlighting their potential as new drug candidates for various diseases.This review summarizes the biological activities of hydrazones, a class of compounds with diverse therapeutic potential. Hydrazones, containing an azometine group, have been extensively studied for their anticonvulsant, antidepressant, analgesic, anti-inflammatory, antimalarial, antimicrobial, antimycobacterial, antitumoral, vasodilator, and antiviral properties. The review highlights the synthesis and evaluation of various hydrazones, emphasizing their biological activities against pathogens and cancer cells. Key findings include the antitubercular activity of isoniazid derivatives, the antimicrobial effects of certain hydrazones against bacteria and fungi, and the antitumoral activity of several hydrazones. Additionally, the review discusses the antiviral activity of some hydrazones against viruses such as HIV and the vasodilator effects of certain compounds. The study also covers the antimycobacterial activity of various hydrazones, including their effectiveness against drug-resistant strains of Mycobacterium tuberculosis. The review concludes with a critical evaluation of the pharmacological activity of hydrazones over the past decade, highlighting their potential as new drug candidates for various diseases.