The article reviews the biological activities of hydrazones, a class of compounds with diverse pharmacological properties. Hydrazones, characterized by the structure -NHN=CH-, have been extensively studied for their potential in drug development due to their ability to exhibit various biological activities. The review covers the synthesis and evaluation of hydrazones for their anticonvulsant, antidepressant, analgesic, anti-inflammatory, antiplatelet, antimalarial, antimicrobial, antimycobacterial, antitumor, vasodilator, antiviral, and antischistosomal activities. Specific compounds and their mechanisms of action are discussed, highlighting their effectiveness in treating conditions such as epilepsy, depression, inflammation, and microbial infections. The review also discusses the synthesis methods and structural modifications that have led to the development of more potent and selective hydrazones.The article reviews the biological activities of hydrazones, a class of compounds with diverse pharmacological properties. Hydrazones, characterized by the structure -NHN=CH-, have been extensively studied for their potential in drug development due to their ability to exhibit various biological activities. The review covers the synthesis and evaluation of hydrazones for their anticonvulsant, antidepressant, analgesic, anti-inflammatory, antiplatelet, antimalarial, antimicrobial, antimycobacterial, antitumor, vasodilator, antiviral, and antischistosomal activities. Specific compounds and their mechanisms of action are discussed, highlighting their effectiveness in treating conditions such as epilepsy, depression, inflammation, and microbial infections. The review also discusses the synthesis methods and structural modifications that have led to the development of more potent and selective hydrazones.