The article reviews the development and application of biomaterials with antioxidant properties to treat oxidative stress diseases. Oxidative stress, characterized by an imbalance between reactive oxygen species (ROS) and antioxidants, leads to detrimental effects such as inflammation and chronic diseases. The low bioavailability of antioxidant compounds is a significant challenge in their therapeutic use. Biomaterials with antioxidant capacity are proposed as a solution to overcome this issue, allowing controlled and targeted release of antioxidants into affected tissues. The review covers the main causes and effects of oxidative stress, focusing on the treatment of chronic wounds, neurodegenerative diseases, cardiovascular diseases, and osteoporosis. It highlights the potential of biomaterials in tissue engineering, particularly in promoting wound healing, reducing inflammation, and preventing disease progression. The article also discusses the challenges and future directions in the development and application of these biomaterials, emphasizing their role in advancing the treatment of oxidative stress-related disorders.The article reviews the development and application of biomaterials with antioxidant properties to treat oxidative stress diseases. Oxidative stress, characterized by an imbalance between reactive oxygen species (ROS) and antioxidants, leads to detrimental effects such as inflammation and chronic diseases. The low bioavailability of antioxidant compounds is a significant challenge in their therapeutic use. Biomaterials with antioxidant capacity are proposed as a solution to overcome this issue, allowing controlled and targeted release of antioxidants into affected tissues. The review covers the main causes and effects of oxidative stress, focusing on the treatment of chronic wounds, neurodegenerative diseases, cardiovascular diseases, and osteoporosis. It highlights the potential of biomaterials in tissue engineering, particularly in promoting wound healing, reducing inflammation, and preventing disease progression. The article also discusses the challenges and future directions in the development and application of these biomaterials, emphasizing their role in advancing the treatment of oxidative stress-related disorders.