Biomaterials-Based Antioxidant Strategies for the Treatment of Oxidative Stress Diseases Oxidative stress is characterized by an imbalance between reactive oxygen species (ROS) and antioxidants, leading to inflammation and chronic diseases such as wound healing impairment, neurodegenerative disorders, cardiovascular diseases, and osteoporosis. Antioxidant compounds face challenges due to low bioavailability, prompting the development of biomaterials with antioxidant properties. These materials can deliver antioxidants in a controlled and targeted manner, enhancing treatment efficacy for chronic inflammation and oxidative stress-related diseases. This review discusses the causes and effects of oxidative stress, focusing on antioxidant biomaterials used in chronic wound healing, neurodegenerative diseases, cardiovascular diseases (including myocardial infarction, ischemia-reperfusion injury, and atherosclerosis), and osteoporosis. The review highlights the potential of biomaterials in tissue engineering for managing oxidative stress and preventing disease. Antioxidant materials include hydrogels, polymeric scaffolds, and composites. Hydrogels are widely used for wound healing due to their ability to absorb exudate and maintain a moist environment. Antioxidant-loaded hydrogels, such as those containing superoxide dismutase (SOD) or cerium oxide nanoparticles (CeONPs), have shown promise in reducing ROS and promoting wound healing. Other materials, such as chitosan, silver nanoparticles, and polyphenols, also exhibit antioxidant properties and are being explored for their therapeutic potential. In neurodegenerative diseases, antioxidant biomaterials such as CeONPs, carbon nanomaterials, and curcumin-loaded nanoparticles are being investigated for their ability to reduce ROS and prevent protein aggregation. These materials can cross the blood-brain barrier, enabling targeted delivery of antioxidants to the brain. For cardiovascular diseases, antioxidant biomaterials are being developed to mitigate oxidative stress and inflammation. These include inorganic nanoparticles, carbon-based materials, and polymeric nanoparticles loaded with antioxidants such as curcumin, resveratrol, and epigallocatechin-3-gallate (EGCG). These materials have shown potential in reducing ROS and improving tissue repair. Overall, antioxidant biomaterials offer a promising approach for managing oxidative stress-related diseases by providing targeted delivery of antioxidants, enhancing tissue repair, and reducing inflammation. Further research is needed to optimize these materials for clinical applications.Biomaterials-Based Antioxidant Strategies for the Treatment of Oxidative Stress Diseases Oxidative stress is characterized by an imbalance between reactive oxygen species (ROS) and antioxidants, leading to inflammation and chronic diseases such as wound healing impairment, neurodegenerative disorders, cardiovascular diseases, and osteoporosis. Antioxidant compounds face challenges due to low bioavailability, prompting the development of biomaterials with antioxidant properties. These materials can deliver antioxidants in a controlled and targeted manner, enhancing treatment efficacy for chronic inflammation and oxidative stress-related diseases. This review discusses the causes and effects of oxidative stress, focusing on antioxidant biomaterials used in chronic wound healing, neurodegenerative diseases, cardiovascular diseases (including myocardial infarction, ischemia-reperfusion injury, and atherosclerosis), and osteoporosis. The review highlights the potential of biomaterials in tissue engineering for managing oxidative stress and preventing disease. Antioxidant materials include hydrogels, polymeric scaffolds, and composites. Hydrogels are widely used for wound healing due to their ability to absorb exudate and maintain a moist environment. Antioxidant-loaded hydrogels, such as those containing superoxide dismutase (SOD) or cerium oxide nanoparticles (CeONPs), have shown promise in reducing ROS and promoting wound healing. Other materials, such as chitosan, silver nanoparticles, and polyphenols, also exhibit antioxidant properties and are being explored for their therapeutic potential. In neurodegenerative diseases, antioxidant biomaterials such as CeONPs, carbon nanomaterials, and curcumin-loaded nanoparticles are being investigated for their ability to reduce ROS and prevent protein aggregation. These materials can cross the blood-brain barrier, enabling targeted delivery of antioxidants to the brain. For cardiovascular diseases, antioxidant biomaterials are being developed to mitigate oxidative stress and inflammation. These include inorganic nanoparticles, carbon-based materials, and polymeric nanoparticles loaded with antioxidants such as curcumin, resveratrol, and epigallocatechin-3-gallate (EGCG). These materials have shown potential in reducing ROS and improving tissue repair. Overall, antioxidant biomaterials offer a promising approach for managing oxidative stress-related diseases by providing targeted delivery of antioxidants, enhancing tissue repair, and reducing inflammation. Further research is needed to optimize these materials for clinical applications.