This study presents a novel biomimetic self-propelled nanomotor with an asymmetric structure for the targeted treatment of neurological inflammatory diseases. The nanomotor, designed to mimic macrophages, is composed of a mesoporous SiO₂ head and multiple MnO₂ tentacles. It is coated with macrophage membrane vesicles to enhance its ability to cross the blood-brain barrier (BBB) and accumulate in inflamed brain regions. The MnO₂ agents catalyze the degradation of H₂O₂ into O₂, providing both anti-inflammatory effects and a driving force for deep brain penetration. Curcumin, loaded into the mesoporous SiO₂ head, regulates macrophage polarization from the M1 to the M2 phenotype. In vitro and in vivo experiments, including cell models, organoids, and animal studies, confirmed the effectiveness of these nanomotors in precise targeting, deep brain penetration, and anti-inflammatory actions. The study highlights the potential of this platform for the treatment of neurological inflammatory diseases.This study presents a novel biomimetic self-propelled nanomotor with an asymmetric structure for the targeted treatment of neurological inflammatory diseases. The nanomotor, designed to mimic macrophages, is composed of a mesoporous SiO₂ head and multiple MnO₂ tentacles. It is coated with macrophage membrane vesicles to enhance its ability to cross the blood-brain barrier (BBB) and accumulate in inflamed brain regions. The MnO₂ agents catalyze the degradation of H₂O₂ into O₂, providing both anti-inflammatory effects and a driving force for deep brain penetration. Curcumin, loaded into the mesoporous SiO₂ head, regulates macrophage polarization from the M1 to the M2 phenotype. In vitro and in vivo experiments, including cell models, organoids, and animal studies, confirmed the effectiveness of these nanomotors in precise targeting, deep brain penetration, and anti-inflammatory actions. The study highlights the potential of this platform for the treatment of neurological inflammatory diseases.