The article reviews the current approaches in biomimetic materials for tissue engineering, focusing on the synthesis of biomimetic materials, novel processing technologies, and biologic delivery strategies. Biomimetic materials are designed to mimic the natural extracellular matrix (ECM) to facilitate cell recruitment, adhesion, proliferation, and differentiation. The review highlights the importance of biodegradability, mechanical properties, and nano-fibrous architecture in enhancing cellular and tissue functions. It also discusses the use of composite and nano-composite materials, surface modification techniques, and bioactive molecule delivery systems. The biological effects of nano-fibrous architecture are demonstrated through enhanced cell adhesion, proliferation, and mineral deposition. The article concludes by emphasizing the continuous evolution of biomimetic approaches in scaffolding materials design, which will advance the field of tissue engineering and regenerative medicine.The article reviews the current approaches in biomimetic materials for tissue engineering, focusing on the synthesis of biomimetic materials, novel processing technologies, and biologic delivery strategies. Biomimetic materials are designed to mimic the natural extracellular matrix (ECM) to facilitate cell recruitment, adhesion, proliferation, and differentiation. The review highlights the importance of biodegradability, mechanical properties, and nano-fibrous architecture in enhancing cellular and tissue functions. It also discusses the use of composite and nano-composite materials, surface modification techniques, and bioactive molecule delivery systems. The biological effects of nano-fibrous architecture are demonstrated through enhanced cell adhesion, proliferation, and mineral deposition. The article concludes by emphasizing the continuous evolution of biomimetic approaches in scaffolding materials design, which will advance the field of tissue engineering and regenerative medicine.