This study explores the combined anti-tumor mechanism of cold exposure therapy (CE) and photodynamic therapy (PDT) using a bionic aggregation-induced emission (AIE) photosensitizer system named THL. THL, which combines tumor-derived exosomes with AIE photosensitizers, is designed to target and enrich at the tumor site. Under external illumination, THL generates hydroxyl radicals and superoxide anions through type I PDT, enhancing tumor cell killing. CE pretreatment reduces ATP and glutathione (GSH) levels in tumor tissue, further enhancing THL-mediated PDT and ROS generation. In vitro and in vivo studies demonstrate that the combination therapy effectively inhibits tumor growth, induces immunogenic cell death (ICD), promotes dendritic cell (DC) maturation, and increases the number of cytotoxic CD8+ T cells and memory T cells. Compared to PDT alone, the combination therapy shows greater advantages in tumor immunotherapy, providing new insights for cancer immunotherapy. The study highlights the potential of combining CE with PDT to achieve enhanced therapeutic effects in cancer treatment.This study explores the combined anti-tumor mechanism of cold exposure therapy (CE) and photodynamic therapy (PDT) using a bionic aggregation-induced emission (AIE) photosensitizer system named THL. THL, which combines tumor-derived exosomes with AIE photosensitizers, is designed to target and enrich at the tumor site. Under external illumination, THL generates hydroxyl radicals and superoxide anions through type I PDT, enhancing tumor cell killing. CE pretreatment reduces ATP and glutathione (GSH) levels in tumor tissue, further enhancing THL-mediated PDT and ROS generation. In vitro and in vivo studies demonstrate that the combination therapy effectively inhibits tumor growth, induces immunogenic cell death (ICD), promotes dendritic cell (DC) maturation, and increases the number of cytotoxic CD8+ T cells and memory T cells. Compared to PDT alone, the combination therapy shows greater advantages in tumor immunotherapy, providing new insights for cancer immunotherapy. The study highlights the potential of combining CE with PDT to achieve enhanced therapeutic effects in cancer treatment.