Blautia is a genus of anaerobic bacteria with probiotic properties, widely present in the intestines and feces of mammals. Recent studies have reclassified several species from Clostridium and Ruminococcus into Blautia, resulting in 20 recognized species. Blautia plays a significant role in host health through biotransformation, regulating metabolism, and modulating the gut microbiota. It is involved in the metabolism of various bioactive compounds, including flavonoids, curcumin, and polyphenols, and can produce secondary metabolites such as bacteriocins, which have antibacterial properties. Blautia is also associated with obesity-related diseases, inflammatory conditions, and metabolic disorders. Its abundance is negatively correlated with certain diseases, such as type 2 diabetes and inflammatory bowel disease, but higher levels have been observed in some conditions like ulcerative colitis. Blautia interacts with other gut microbes through cross-feeding, influencing metabolic pathways and contributing to the stability of the intestinal microbiota. Despite its potential probiotic functions, the exact mechanisms and species-specific effects of Blautia remain under investigation. Further research is needed to fully understand its role in human health and to develop new probiotic applications.Blautia is a genus of anaerobic bacteria with probiotic properties, widely present in the intestines and feces of mammals. Recent studies have reclassified several species from Clostridium and Ruminococcus into Blautia, resulting in 20 recognized species. Blautia plays a significant role in host health through biotransformation, regulating metabolism, and modulating the gut microbiota. It is involved in the metabolism of various bioactive compounds, including flavonoids, curcumin, and polyphenols, and can produce secondary metabolites such as bacteriocins, which have antibacterial properties. Blautia is also associated with obesity-related diseases, inflammatory conditions, and metabolic disorders. Its abundance is negatively correlated with certain diseases, such as type 2 diabetes and inflammatory bowel disease, but higher levels have been observed in some conditions like ulcerative colitis. Blautia interacts with other gut microbes through cross-feeding, influencing metabolic pathways and contributing to the stability of the intestinal microbiota. Despite its potential probiotic functions, the exact mechanisms and species-specific effects of Blautia remain under investigation. Further research is needed to fully understand its role in human health and to develop new probiotic applications.