This paper presents a blockchain-based security solution for ensuring the integrity and provenance of medical device data in cloud environments. The proposed system addresses the challenges of data integrity, security, and provenance in centralized medical device data management systems, which are vulnerable to single points of failure, data breaches, and data manipulation. The solution leverages blockchain technology, which offers a decentralized, immutable, and transparent approach to data management. The system architecture integrates medical devices, a cloud platform, and a blockchain solution, enabling secure and tamper-proof data storage, access control, and audit trails. The proposed solution uses smart contracts, cryptographic techniques, and consensus mechanisms to ensure data integrity and provenance throughout the data lifecycle. It also incorporates data encryption, access control, and regulatory compliance to protect patient privacy and ensure data security. The system is designed to be scalable, efficient, and compliant with regulations such as HIPAA and GDPR. The results of the performance evaluation show that the proposed solution can handle large volumes of medical device data with acceptable performance levels. The security testing confirmed the absence of critical vulnerabilities, and the regulatory compliance testing demonstrated high-level compliance with relevant standards. The solution provides a secure, transparent, and reliable way to manage medical device data in cloud environments, supporting patient safety, regulatory compliance, and trust in the healthcare sector. Future research directions include performance optimization, scalability enhancements, integration with existing healthcare systems, advanced privacy-preserving techniques, regulatory compliance improvements, real-world deployment, blockchain interoperability, and decentralized identity management.This paper presents a blockchain-based security solution for ensuring the integrity and provenance of medical device data in cloud environments. The proposed system addresses the challenges of data integrity, security, and provenance in centralized medical device data management systems, which are vulnerable to single points of failure, data breaches, and data manipulation. The solution leverages blockchain technology, which offers a decentralized, immutable, and transparent approach to data management. The system architecture integrates medical devices, a cloud platform, and a blockchain solution, enabling secure and tamper-proof data storage, access control, and audit trails. The proposed solution uses smart contracts, cryptographic techniques, and consensus mechanisms to ensure data integrity and provenance throughout the data lifecycle. It also incorporates data encryption, access control, and regulatory compliance to protect patient privacy and ensure data security. The system is designed to be scalable, efficient, and compliant with regulations such as HIPAA and GDPR. The results of the performance evaluation show that the proposed solution can handle large volumes of medical device data with acceptable performance levels. The security testing confirmed the absence of critical vulnerabilities, and the regulatory compliance testing demonstrated high-level compliance with relevant standards. The solution provides a secure, transparent, and reliable way to manage medical device data in cloud environments, supporting patient safety, regulatory compliance, and trust in the healthcare sector. Future research directions include performance optimization, scalability enhancements, integration with existing healthcare systems, advanced privacy-preserving techniques, regulatory compliance improvements, real-world deployment, blockchain interoperability, and decentralized identity management.