The paper presents the synthesis and characterization of heterostructured platinum-palladium alloy and oxide nanowires (PtPd-ox NWs) for formate electrooxidation (FOR) in direct formate fuel cells (DFFCs). The PtPd-ox NWs are synthesized using a self-template method, which involves the use of complexes of dimethylglyoxime (DMG) with Pd(II) and Pt(II) as precursors. The optimal composition of PtPd-ox NWs is found to exhibit high FOR activity and stability due to its unique electronic properties. The heterojunction between the alloy and oxides influences the work function of the NWs, leading to favorable adsorption behavior for intermediates and strong $d-p$ orbital hybridization between the Pt site and oxygen in formate. This results in a low energy barrier for the direct pathway of FOR. Additionally, the heterostructure provides sufficient hydroxyl species to facilitate the formation of carbon dioxide, improving the kinetics of FOR. The performance of PtPd-ox NWs is evaluated in DFFCs devices, demonstrating their potential for practical applications. The study highlights the dual regulation of FOR thermodynamics and kinetics achieved by the heterostructured PtPd-ox NWs.The paper presents the synthesis and characterization of heterostructured platinum-palladium alloy and oxide nanowires (PtPd-ox NWs) for formate electrooxidation (FOR) in direct formate fuel cells (DFFCs). The PtPd-ox NWs are synthesized using a self-template method, which involves the use of complexes of dimethylglyoxime (DMG) with Pd(II) and Pt(II) as precursors. The optimal composition of PtPd-ox NWs is found to exhibit high FOR activity and stability due to its unique electronic properties. The heterojunction between the alloy and oxides influences the work function of the NWs, leading to favorable adsorption behavior for intermediates and strong $d-p$ orbital hybridization between the Pt site and oxygen in formate. This results in a low energy barrier for the direct pathway of FOR. Additionally, the heterostructure provides sufficient hydroxyl species to facilitate the formation of carbon dioxide, improving the kinetics of FOR. The performance of PtPd-ox NWs is evaluated in DFFCs devices, demonstrating their potential for practical applications. The study highlights the dual regulation of FOR thermodynamics and kinetics achieved by the heterostructured PtPd-ox NWs.