The article "Bringing Immunofocusing into Focus" by Sriharshita Musunuri, Payton A. B. Weidenbacher, and Peter S. Kim discusses the strategy of immunofocusing, which aims to create immunogens that redirect the humoral immune response towards a specific epitope while minimizing responses to non-desirable epitopes. The authors highlight five main immunofocusing strategies: cross-strain boosting, mosaic display, protein dissection, epitope scaffolding, and epitope masking. Each strategy is explained with examples and considerations, emphasizing the importance of high-resolution immunofocusing to design vaccines that can provide broad protection against highly variant viruses such as influenza, HIV-1, and SARS-CoV-2. The article also addresses challenges like immune imprinting and the need for iterative vaccine design to overcome pre-existing immunity. The authors conclude by discussing the potential of combining multiple immunofocusing methods to enhance vaccine efficacy and the importance of computational tools in predicting viral escape and designing effective immunogens.The article "Bringing Immunofocusing into Focus" by Sriharshita Musunuri, Payton A. B. Weidenbacher, and Peter S. Kim discusses the strategy of immunofocusing, which aims to create immunogens that redirect the humoral immune response towards a specific epitope while minimizing responses to non-desirable epitopes. The authors highlight five main immunofocusing strategies: cross-strain boosting, mosaic display, protein dissection, epitope scaffolding, and epitope masking. Each strategy is explained with examples and considerations, emphasizing the importance of high-resolution immunofocusing to design vaccines that can provide broad protection against highly variant viruses such as influenza, HIV-1, and SARS-CoV-2. The article also addresses challenges like immune imprinting and the need for iterative vaccine design to overcome pre-existing immunity. The authors conclude by discussing the potential of combining multiple immunofocusing methods to enhance vaccine efficacy and the importance of computational tools in predicting viral escape and designing effective immunogens.