This study provides global estimates for the burden of otitis media (OM), including acute otitis media (AOM), chronic suppurative otitis media (CSOM), and related hearing impairment (HI) and mortality. The research, based on a systematic review of literature and data from 21 WHO regions, found that AOM incidence is 10.85% (709 million cases annually), with 51% occurring in children under five. CSOM incidence is 4.76% (31 million cases annually), with 22.6% occurring in children under five. HI prevalence is 30.82 per ten-thousand, and 21,000 people die annually due to OM complications. The study highlights the significant burden of OM, particularly in the first five years of life and in poorer countries. It emphasizes the need for targeted interventions to reduce the health, social, and economic impact of OM, including prevention strategies, improved care-seeking, and effective treatment. The findings call for incorporating OM-focused actions into broader health and prevention strategies, with a focus on high-burden regions. The study also underscores the importance of addressing risk factors such as malnutrition, smoking, and exposure to indoor air pollution, as well as the role of vaccines in reducing OM-related morbidity and mortality. The research provides a comprehensive understanding of the global burden of OM and its sequelae, which is essential for informing public health policies and interventions.This study provides global estimates for the burden of otitis media (OM), including acute otitis media (AOM), chronic suppurative otitis media (CSOM), and related hearing impairment (HI) and mortality. The research, based on a systematic review of literature and data from 21 WHO regions, found that AOM incidence is 10.85% (709 million cases annually), with 51% occurring in children under five. CSOM incidence is 4.76% (31 million cases annually), with 22.6% occurring in children under five. HI prevalence is 30.82 per ten-thousand, and 21,000 people die annually due to OM complications. The study highlights the significant burden of OM, particularly in the first five years of life and in poorer countries. It emphasizes the need for targeted interventions to reduce the health, social, and economic impact of OM, including prevention strategies, improved care-seeking, and effective treatment. The findings call for incorporating OM-focused actions into broader health and prevention strategies, with a focus on high-burden regions. The study also underscores the importance of addressing risk factors such as malnutrition, smoking, and exposure to indoor air pollution, as well as the role of vaccines in reducing OM-related morbidity and mortality. The research provides a comprehensive understanding of the global burden of OM and its sequelae, which is essential for informing public health policies and interventions.