This systematic review examines the global burden of cardiovascular diseases (CVDs) attributed to air pollution, focusing on prevalence, hospitalization, disability, mortality, and cost. The study included 92 eligible articles from databases such as Scopus, PubMed, and Web of Science, published up to June 13, 2023. The main pollutants investigated were PM2.5 and NO2, which were closely associated with hypertension. The results showed that chronic exposure to air pollutants increased the prevalence, hospitalization, disability (measured in disability-adjusted life years [DALY], years lost due to disability [YLD], and years of life lost [YLL]), and mortality of CVDs. Specifically, the DALY rate caused by PM2.5 exposure increased from 10 million years in 1990 to 20 million years in 2019. Hospitalization rates for CVDs were also significantly influenced by air pollution, with PM2.5 and PM10 being the most common pollutants. The economic burden of CVDs attributed to air pollution was substantial, with PM2.5 causing the highest economic losses. The study highlights the need for preventive measures and policy interventions to reduce the impact of air pollution on CVDs, emphasizing the importance of addressing this environmental threat to public health.This systematic review examines the global burden of cardiovascular diseases (CVDs) attributed to air pollution, focusing on prevalence, hospitalization, disability, mortality, and cost. The study included 92 eligible articles from databases such as Scopus, PubMed, and Web of Science, published up to June 13, 2023. The main pollutants investigated were PM2.5 and NO2, which were closely associated with hypertension. The results showed that chronic exposure to air pollutants increased the prevalence, hospitalization, disability (measured in disability-adjusted life years [DALY], years lost due to disability [YLD], and years of life lost [YLL]), and mortality of CVDs. Specifically, the DALY rate caused by PM2.5 exposure increased from 10 million years in 1990 to 20 million years in 2019. Hospitalization rates for CVDs were also significantly influenced by air pollution, with PM2.5 and PM10 being the most common pollutants. The economic burden of CVDs attributed to air pollution was substantial, with PM2.5 causing the highest economic losses. The study highlights the need for preventive measures and policy interventions to reduce the impact of air pollution on CVDs, emphasizing the importance of addressing this environmental threat to public health.