This study provides an updated assessment of the burden of gastrointestinal (GI) disease in the United States. It uses data from multiple national databases to estimate the prevalence, cost, and impact of GI diseases. The most common GI symptoms prompting clinic visits in 2009 were abdominal pain and gastroesophageal reflux. Gastroesophageal reflux was the most common GI diagnosis, with over 8.9 million visits. Acute pancreatitis was the most common reason for hospitalization, with over 274,000 discharges. Colorectal cancer accounted for more than half of all GI cancers and was the leading cause of GI-related mortality, with over 52,000 deaths. Clostridium difficile infection hospitalizations have doubled in the last 10 years. The total cost for outpatient gastrointestinal endoscopy examinations in 2009 was $32.4 billion. There were an estimated 6.9 million upper, 11.5 million lower, and 228,000 biliary endoscopies performed in the United States in 2009. The study also examined trends in endoscopic utilization and found that the number of endoscopic procedures has increased significantly over the past decade. The study highlights the significant burden of GI diseases on the U.S. population, including high morbidity, mortality, and healthcare costs. It emphasizes the need for continued research, education, and resource allocation to address the challenges posed by these diseases. The findings underscore the importance of understanding the impact of GI diseases on quality of life, work productivity, and healthcare utilization. The study also notes the increasing prevalence of conditions such as obesity and C. difficile infection, which have significant implications for public health. Overall, the study provides a comprehensive overview of the current state of GI disease in the United States and highlights the need for further research and policy action.This study provides an updated assessment of the burden of gastrointestinal (GI) disease in the United States. It uses data from multiple national databases to estimate the prevalence, cost, and impact of GI diseases. The most common GI symptoms prompting clinic visits in 2009 were abdominal pain and gastroesophageal reflux. Gastroesophageal reflux was the most common GI diagnosis, with over 8.9 million visits. Acute pancreatitis was the most common reason for hospitalization, with over 274,000 discharges. Colorectal cancer accounted for more than half of all GI cancers and was the leading cause of GI-related mortality, with over 52,000 deaths. Clostridium difficile infection hospitalizations have doubled in the last 10 years. The total cost for outpatient gastrointestinal endoscopy examinations in 2009 was $32.4 billion. There were an estimated 6.9 million upper, 11.5 million lower, and 228,000 biliary endoscopies performed in the United States in 2009. The study also examined trends in endoscopic utilization and found that the number of endoscopic procedures has increased significantly over the past decade. The study highlights the significant burden of GI diseases on the U.S. population, including high morbidity, mortality, and healthcare costs. It emphasizes the need for continued research, education, and resource allocation to address the challenges posed by these diseases. The findings underscore the importance of understanding the impact of GI diseases on quality of life, work productivity, and healthcare utilization. The study also notes the increasing prevalence of conditions such as obesity and C. difficile infection, which have significant implications for public health. Overall, the study provides a comprehensive overview of the current state of GI disease in the United States and highlights the need for further research and policy action.