The chapter discusses the C-reactive protein (CRP), a highly conserved plasma protein that plays a crucial role in the systemic response to inflammation. Initially discovered in the serum of patients with acute inflammation, CRP is now known to be a native protein synthesized by the liver. It is a pattern recognition molecule that binds to specific molecular configurations, contributing to host defense and the innate immune response. The chapter covers the molecular structure of CRP, its functions, and its clinical applications, particularly as a marker of inflammation. Various analytical methods for CRP determination are described, including ELISA, immunoturbidimetry, and rapid immunodiffusion. The chapter also highlights the use of high-sensitivity CRP (hs-CRP) testing in predicting cardiovascular disease risk and its role in diagnosing postoperative infections and bacterial meningitis. Additionally, it explores natural treatments for reducing CRP levels, such as fish oil, ginger, and MSM, and the potential of vitamin C in lowering chronic inflammation.The chapter discusses the C-reactive protein (CRP), a highly conserved plasma protein that plays a crucial role in the systemic response to inflammation. Initially discovered in the serum of patients with acute inflammation, CRP is now known to be a native protein synthesized by the liver. It is a pattern recognition molecule that binds to specific molecular configurations, contributing to host defense and the innate immune response. The chapter covers the molecular structure of CRP, its functions, and its clinical applications, particularly as a marker of inflammation. Various analytical methods for CRP determination are described, including ELISA, immunoturbidimetry, and rapid immunodiffusion. The chapter also highlights the use of high-sensitivity CRP (hs-CRP) testing in predicting cardiovascular disease risk and its role in diagnosing postoperative infections and bacterial meningitis. Additionally, it explores natural treatments for reducing CRP levels, such as fish oil, ginger, and MSM, and the potential of vitamin C in lowering chronic inflammation.