The paper presents a selection guide for common solvents, developed by the CHEM21 consortium, which aims to promote sustainable biological and chemical methodologies. The guide ranks solvents based on Safety, Health, and Environment (SH&E) criteria, aligned with the Global Harmonized System (GHS) and European regulations. The methodology combines these criteria into a scoring system, allowing for a preliminary ranking of solvents into four categories: recommended, problematic, hazardous, and highly hazardous. The guide also includes a simplified evaluation of bio-derived solvents. The authors discuss the methodology's limitations and its applicability to less common solvents, emphasizing the importance of further data and studies to refine the rankings. The guide is intended to assist in the selection of more environmentally friendly solvents in pharmaceutical and chemical industries.The paper presents a selection guide for common solvents, developed by the CHEM21 consortium, which aims to promote sustainable biological and chemical methodologies. The guide ranks solvents based on Safety, Health, and Environment (SH&E) criteria, aligned with the Global Harmonized System (GHS) and European regulations. The methodology combines these criteria into a scoring system, allowing for a preliminary ranking of solvents into four categories: recommended, problematic, hazardous, and highly hazardous. The guide also includes a simplified evaluation of bio-derived solvents. The authors discuss the methodology's limitations and its applicability to less common solvents, emphasizing the importance of further data and studies to refine the rankings. The guide is intended to assist in the selection of more environmentally friendly solvents in pharmaceutical and chemical industries.