This paper presents a selection guide of solvents based on a survey of publicly available solvent selection guides. The guide includes Safety, Health, and Environment (SH&E) criteria aligned with the Global Harmonized System (GHS) and European regulations. A methodology combining these criteria provides an overall ranking of solvents, enabling a simplified greenness evaluation of bio-derived solvents. The guide is developed by the CHEM21 public-private partnership, which aims to promote sustainable biological and chemical methodologies. Solvents represent at least half of the material used in a chemical process, so selecting the "greenest" solvents is crucial for reducing environmental impact. The guide ranks solvents into four categories: recommended, problematic, hazardous, and highly hazardous. The rankings are based on criteria such as flammability, toxicity, and environmental impact. The safety score considers flammability and other hazards, while the health score is based on occupational exposure limits and hazard statements. The environmental score includes factors like acute toxicity, bioaccumulation, and recyclability. The guide includes both classical and less classical solvents, with a focus on bio-derived solvents. It also provides a framework for evaluating the environmental impact of solvents, including their carbon footprint and energy demand. The guide is intended to help in the selection of solvents for pharmaceutical and chemical processes, with the goal of promoting sustainable practices. The methodology has been applied to 53 common solvents, with the rankings generally aligning with existing solvent guides. The guide also includes a ranking for less common solvents, such as ionic liquids and supercritical fluids. The rankings are based on a combination of criteria, including toxicity, environmental impact, and industrial feasibility. The guide highlights the importance of considering the environmental impact of solvents, including their recyclability and potential for bioaccumulation. It also emphasizes the need for data transparency and the importance of publishing toxicity data to allow for accurate rankings. The guide is intended to be a valuable resource for chemists and pharmaceutical companies seeking to promote sustainable practices in solvent selection.This paper presents a selection guide of solvents based on a survey of publicly available solvent selection guides. The guide includes Safety, Health, and Environment (SH&E) criteria aligned with the Global Harmonized System (GHS) and European regulations. A methodology combining these criteria provides an overall ranking of solvents, enabling a simplified greenness evaluation of bio-derived solvents. The guide is developed by the CHEM21 public-private partnership, which aims to promote sustainable biological and chemical methodologies. Solvents represent at least half of the material used in a chemical process, so selecting the "greenest" solvents is crucial for reducing environmental impact. The guide ranks solvents into four categories: recommended, problematic, hazardous, and highly hazardous. The rankings are based on criteria such as flammability, toxicity, and environmental impact. The safety score considers flammability and other hazards, while the health score is based on occupational exposure limits and hazard statements. The environmental score includes factors like acute toxicity, bioaccumulation, and recyclability. The guide includes both classical and less classical solvents, with a focus on bio-derived solvents. It also provides a framework for evaluating the environmental impact of solvents, including their carbon footprint and energy demand. The guide is intended to help in the selection of solvents for pharmaceutical and chemical processes, with the goal of promoting sustainable practices. The methodology has been applied to 53 common solvents, with the rankings generally aligning with existing solvent guides. The guide also includes a ranking for less common solvents, such as ionic liquids and supercritical fluids. The rankings are based on a combination of criteria, including toxicity, environmental impact, and industrial feasibility. The guide highlights the importance of considering the environmental impact of solvents, including their recyclability and potential for bioaccumulation. It also emphasizes the need for data transparency and the importance of publishing toxicity data to allow for accurate rankings. The guide is intended to be a valuable resource for chemists and pharmaceutical companies seeking to promote sustainable practices in solvent selection.