This review paper explores the dynamics, challenges, and successes of Africa-US collaborations in e-Government, emphasizing the significant impact of digital governance initiatives on improving public service delivery and governance. The paper examines theoretical frameworks, key concepts, and contextual differences to synthesize lessons learned and best practices from these international collaborations. It identifies critical success factors such as leadership, stakeholder engagement, and capacity building, while addressing common challenges like the digital divide and technological infrastructure. Emerging trends such as artificial intelligence, blockchain, and digital identity systems offer new avenues for future collaborations. The paper concludes with recommendations for strengthening partnerships, including technology transfer, policy harmonization, and alignment with sustainable development goals. The review highlights the importance of mutual learning and adaptation to specific environmental, cultural, and economic realities, emphasizing the need for tailored strategies and sustainable funding models.This review paper explores the dynamics, challenges, and successes of Africa-US collaborations in e-Government, emphasizing the significant impact of digital governance initiatives on improving public service delivery and governance. The paper examines theoretical frameworks, key concepts, and contextual differences to synthesize lessons learned and best practices from these international collaborations. It identifies critical success factors such as leadership, stakeholder engagement, and capacity building, while addressing common challenges like the digital divide and technological infrastructure. Emerging trends such as artificial intelligence, blockchain, and digital identity systems offer new avenues for future collaborations. The paper concludes with recommendations for strengthening partnerships, including technology transfer, policy harmonization, and alignment with sustainable development goals. The review highlights the importance of mutual learning and adaptation to specific environmental, cultural, and economic realities, emphasizing the need for tailored strategies and sustainable funding models.