This study presents a morphometric model and stereologic methods to quantitatively characterize the functional parameters of liver cells in normal rats. The model defines the basic morphological properties of hepatocytes, and the stereologic methods allow efficient and reliable evaluation of sectioned liver tissue. The study uses a rigorous three-stage sampling procedure from five normal rat livers, analyzing the tissue at four levels of magnification to obtain quantitative data expressed as "densities," "specific dimensions," and "absolute dimensions." Key findings include the number of hepatocyte nuclei (169 × 10^6 per ml of tissue), the volume of hepatocyte cytoplasm (77% of liver volume), and the surface area of endoplasmic reticulum membranes (11 m^2 per ml of tissue). The study also discusses the validity and applicability of the method, comparing the data with other studies. The results provide a baseline for future correlated experimental studies on structural and biochemical alterations in liver cells induced by various compounds.This study presents a morphometric model and stereologic methods to quantitatively characterize the functional parameters of liver cells in normal rats. The model defines the basic morphological properties of hepatocytes, and the stereologic methods allow efficient and reliable evaluation of sectioned liver tissue. The study uses a rigorous three-stage sampling procedure from five normal rat livers, analyzing the tissue at four levels of magnification to obtain quantitative data expressed as "densities," "specific dimensions," and "absolute dimensions." Key findings include the number of hepatocyte nuclei (169 × 10^6 per ml of tissue), the volume of hepatocyte cytoplasm (77% of liver volume), and the surface area of endoplasmic reticulum membranes (11 m^2 per ml of tissue). The study also discusses the validity and applicability of the method, comparing the data with other studies. The results provide a baseline for future correlated experimental studies on structural and biochemical alterations in liver cells induced by various compounds.