This study presents a morphometric model and stereologic methods for analyzing liver cell structure in normal rats. The research uses a rigorous three-stage sampling procedure to examine five normal rat livers at four magnification levels. The data obtained includes quantitative information on hepatocyte nuclei, other cell nuclei, and mitochondria. The study provides baseline data for various parameters, such as the volume of hepatocyte cytoplasm (77% of liver volume) and mitochondria (18% of liver volume). The surface area of endoplasmic reticulum membranes in 1 ml of liver tissue is 11 m², with 2/3 of this area being rough ER and containing about 2×10¹⁸ ribosomes. The surface area of mitochondrial cristae in the unit volume is estimated at 6 m². The study discusses the validity and applicability of the method and compares the data with information from other studies. The study also describes the morphometric model of the hepatocyte, which is systematically divided into compartments. The model includes parameters such as volume, surface area, and number of particles. The study uses stereologic methods to estimate these parameters and provides specific dimensions for the normal rat liver. The data is expressed as "densities," "specific dimensions," and "absolute dimensions." The study also discusses the application of stereologic procedures to different magnification levels and the calibration of the electron micrographs. The study presents the results of the morphometric analysis, including the number and size of hepatocytes, the composition of liver tissue, and the polarity of the hepatocyte membrane. The study also discusses the systematic errors that may affect the data, such as the compression of tissue by sectioning and the Holmes effect. The study concludes that the method is valid and applicable for quantitative analysis of liver cell structure. The data provides a baseline for comparative biochemical and morphometric studies of livers under experimental conditions. The study also discusses the limitations of the method and the potential for future research in this area.This study presents a morphometric model and stereologic methods for analyzing liver cell structure in normal rats. The research uses a rigorous three-stage sampling procedure to examine five normal rat livers at four magnification levels. The data obtained includes quantitative information on hepatocyte nuclei, other cell nuclei, and mitochondria. The study provides baseline data for various parameters, such as the volume of hepatocyte cytoplasm (77% of liver volume) and mitochondria (18% of liver volume). The surface area of endoplasmic reticulum membranes in 1 ml of liver tissue is 11 m², with 2/3 of this area being rough ER and containing about 2×10¹⁸ ribosomes. The surface area of mitochondrial cristae in the unit volume is estimated at 6 m². The study discusses the validity and applicability of the method and compares the data with information from other studies. The study also describes the morphometric model of the hepatocyte, which is systematically divided into compartments. The model includes parameters such as volume, surface area, and number of particles. The study uses stereologic methods to estimate these parameters and provides specific dimensions for the normal rat liver. The data is expressed as "densities," "specific dimensions," and "absolute dimensions." The study also discusses the application of stereologic procedures to different magnification levels and the calibration of the electron micrographs. The study presents the results of the morphometric analysis, including the number and size of hepatocytes, the composition of liver tissue, and the polarity of the hepatocyte membrane. The study also discusses the systematic errors that may affect the data, such as the compression of tissue by sectioning and the Holmes effect. The study concludes that the method is valid and applicable for quantitative analysis of liver cell structure. The data provides a baseline for comparative biochemical and morphometric studies of livers under experimental conditions. The study also discusses the limitations of the method and the potential for future research in this area.