COSMIC (Catalogue Of Somatic Mutations In Cancer) is a comprehensive resource for exploring somatic mutations in human cancer. The latest release, COSMIC v86 (August 2018), includes nearly 6 million coding mutations across 1.4 million tumor samples, curated from over 26,000 publications. It covers various genetic mechanisms, including non-coding mutations, gene fusions, copy-number variants, and drug-resistance mutations. COSMIC is primarily hand-curated to ensure quality and accuracy. New initiatives prioritize key genes and diseases, and the data are regularly updated every three months. The Cancer Gene Census (CGC) describes 719 genes driving human cancer, with functional descriptions of their roles in the 10 cancer hallmarks. COSMIC-3D links mutation data with protein structures, facilitating structural and functional analysis. The resource is available through a user-friendly website and downloadable data, with ongoing improvements and future plans for expansion and redevelopment.COSMIC (Catalogue Of Somatic Mutations In Cancer) is a comprehensive resource for exploring somatic mutations in human cancer. The latest release, COSMIC v86 (August 2018), includes nearly 6 million coding mutations across 1.4 million tumor samples, curated from over 26,000 publications. It covers various genetic mechanisms, including non-coding mutations, gene fusions, copy-number variants, and drug-resistance mutations. COSMIC is primarily hand-curated to ensure quality and accuracy. New initiatives prioritize key genes and diseases, and the data are regularly updated every three months. The Cancer Gene Census (CGC) describes 719 genes driving human cancer, with functional descriptions of their roles in the 10 cancer hallmarks. COSMIC-3D links mutation data with protein structures, facilitating structural and functional analysis. The resource is available through a user-friendly website and downloadable data, with ongoing improvements and future plans for expansion and redevelopment.