This comprehensive review by Pascarella et al. provides an overview of the clinical features and treatment options for COVID-19, a disease caused by the novel coronavirus SARS-CoV-2. The authors conducted a systematic literature search using major online databases and identified publications from January 1, 2019, to April 3, 2020, focusing on clinical characteristics and treatments. They found that the virus is transmitted through human-to-human contact and contaminated surfaces, with hand hygiene and personal protective equipment being crucial preventive measures. Common symptoms include fever, cough, fatigue, dyspnea, sore throat, headache, conjunctivitis, and gastrointestinal issues. Real-time PCR is the primary diagnostic tool, and computed tomography (CT) findings are important for diagnosis and follow-up. Currently, there is no specific treatment for COVID-19, but antiviral drugs, chloroquine/hydroxychloroquine, and respiratory therapy are being used. The authors emphasize that quarantine remains the most effective intervention to reduce the contagion rate, and specifically designed randomized clinical trials are needed to determine the most appropriate evidence-based treatment modality.This comprehensive review by Pascarella et al. provides an overview of the clinical features and treatment options for COVID-19, a disease caused by the novel coronavirus SARS-CoV-2. The authors conducted a systematic literature search using major online databases and identified publications from January 1, 2019, to April 3, 2020, focusing on clinical characteristics and treatments. They found that the virus is transmitted through human-to-human contact and contaminated surfaces, with hand hygiene and personal protective equipment being crucial preventive measures. Common symptoms include fever, cough, fatigue, dyspnea, sore throat, headache, conjunctivitis, and gastrointestinal issues. Real-time PCR is the primary diagnostic tool, and computed tomography (CT) findings are important for diagnosis and follow-up. Currently, there is no specific treatment for COVID-19, but antiviral drugs, chloroquine/hydroxychloroquine, and respiratory therapy are being used. The authors emphasize that quarantine remains the most effective intervention to reduce the contagion rate, and specifically designed randomized clinical trials are needed to determine the most appropriate evidence-based treatment modality.