A study conducted in California analyzed the impact of the pediatric COVID-19 vaccination program on the incidence of SARS-CoV-2 infections and hospitalizations among children aged 6 months to 15 years. The research found that the vaccination program significantly reduced the number of reported cases and hospitalizations. For adolescents aged 12 to 15 years, the program averted 146,210 cases (37.1% reduction) during a 141-day post-vaccination period. For children aged 5 to 11 years, the program averted 230,134 cases (23.7% reduction) during a 199-day period. For children aged 6 to 59 months, while no significant reduction in cases was observed, 168 hospitalizations were averted (24.4% reduction). Overall, the program averted 376,085 reported cases and 273 hospitalizations among children aged 6 months to 15 years over 4 to 7 months following vaccine availability. The study used a case series approach, comparing observed rates with counterfactual predictions based on other age groups. County-level vaccination coverage was associated with averted cases for all age groups. The findings suggest that SARS-CoV-2 vaccination was associated with significant reductions in pediatric COVID-19 incidence and hospitalizations. The study also highlights the importance of vaccination coverage in reducing the spread of the virus among children. The results support the use of COVID-19 vaccines to reduce the incidence and hospitalization rates in pediatric populations.A study conducted in California analyzed the impact of the pediatric COVID-19 vaccination program on the incidence of SARS-CoV-2 infections and hospitalizations among children aged 6 months to 15 years. The research found that the vaccination program significantly reduced the number of reported cases and hospitalizations. For adolescents aged 12 to 15 years, the program averted 146,210 cases (37.1% reduction) during a 141-day post-vaccination period. For children aged 5 to 11 years, the program averted 230,134 cases (23.7% reduction) during a 199-day period. For children aged 6 to 59 months, while no significant reduction in cases was observed, 168 hospitalizations were averted (24.4% reduction). Overall, the program averted 376,085 reported cases and 273 hospitalizations among children aged 6 months to 15 years over 4 to 7 months following vaccine availability. The study used a case series approach, comparing observed rates with counterfactual predictions based on other age groups. County-level vaccination coverage was associated with averted cases for all age groups. The findings suggest that SARS-CoV-2 vaccination was associated with significant reductions in pediatric COVID-19 incidence and hospitalizations. The study also highlights the importance of vaccination coverage in reducing the spread of the virus among children. The results support the use of COVID-19 vaccines to reduce the incidence and hospitalization rates in pediatric populations.