This systematic review aims to assess the global acceptance rates of COVID-19 vaccines. A total of 31 studies from 33 countries were included, with the highest acceptance rates found in Ecuador (97.0%), Malaysia (94.3%), Indonesia (93.3%), and China (91.3%). The lowest rates were in Kuwait (23.6%), Jordan (28.4%), Italy (53.7%), Russia (54.9%), Poland (56.3%), the US (56.9%), and France (58.9%). Among healthcare workers, the acceptance rates ranged from 27.7% in the Democratic Republic of the Congo to 78.1% in Israel. The review highlights significant variability in acceptance rates, with low rates particularly in the Middle East, Russia, Africa, and several European countries. These findings underscore the need for targeted interventions to address vaccine hesitancy and build trust in vaccination efforts.This systematic review aims to assess the global acceptance rates of COVID-19 vaccines. A total of 31 studies from 33 countries were included, with the highest acceptance rates found in Ecuador (97.0%), Malaysia (94.3%), Indonesia (93.3%), and China (91.3%). The lowest rates were in Kuwait (23.6%), Jordan (28.4%), Italy (53.7%), Russia (54.9%), Poland (56.3%), the US (56.9%), and France (58.9%). Among healthcare workers, the acceptance rates ranged from 27.7% in the Democratic Republic of the Congo to 78.1% in Israel. The review highlights significant variability in acceptance rates, with low rates particularly in the Middle East, Russia, Africa, and several European countries. These findings underscore the need for targeted interventions to address vaccine hesitancy and build trust in vaccination efforts.