This systematic review evaluates global acceptance rates of the COVID-19 vaccine across 33 countries, based on 31 peer-reviewed studies published between February 2020 and December 2020. The study found that vaccine acceptance varied widely, with high rates in countries like Ecuador (97.0%), Malaysia (94.3%), Indonesia (93.3%), and China (91.3%), while low rates were observed in Kuwait (23.6%), Jordan (28.4%), Italy (53.7%), Russia (54.9%), Poland (56.3%), the US (56.9%), and France (58.9%). Among healthcare workers, acceptance rates ranged from 27.7% in the Democratic Republic of the Congo to 78.1% in Israel. In most countries, over 70% of the general public accepted the vaccine. However, vaccine hesitancy was particularly high in the Middle East, Russia, Africa, and parts of Europe. The review highlights the need for targeted studies in regions with low acceptance rates, such as the Middle East, North Africa, Sub-Saharan Africa, Eastern Europe, Central Asia, and Latin America. Vaccine hesitancy is influenced by factors including perceived risk, trust in vaccines, and cultural beliefs. Addressing these factors is crucial for effective vaccination campaigns and controlling the pandemic. The study underscores the importance of understanding regional differences in vaccine acceptance to improve public health strategies.This systematic review evaluates global acceptance rates of the COVID-19 vaccine across 33 countries, based on 31 peer-reviewed studies published between February 2020 and December 2020. The study found that vaccine acceptance varied widely, with high rates in countries like Ecuador (97.0%), Malaysia (94.3%), Indonesia (93.3%), and China (91.3%), while low rates were observed in Kuwait (23.6%), Jordan (28.4%), Italy (53.7%), Russia (54.9%), Poland (56.3%), the US (56.9%), and France (58.9%). Among healthcare workers, acceptance rates ranged from 27.7% in the Democratic Republic of the Congo to 78.1% in Israel. In most countries, over 70% of the general public accepted the vaccine. However, vaccine hesitancy was particularly high in the Middle East, Russia, Africa, and parts of Europe. The review highlights the need for targeted studies in regions with low acceptance rates, such as the Middle East, North Africa, Sub-Saharan Africa, Eastern Europe, Central Asia, and Latin America. Vaccine hesitancy is influenced by factors including perceived risk, trust in vaccines, and cultural beliefs. Addressing these factors is crucial for effective vaccination campaigns and controlling the pandemic. The study underscores the importance of understanding regional differences in vaccine acceptance to improve public health strategies.