The COVID-19 Resource Centre, established by Elsevier in January 2020, provides free information in English and Mandarin on the novel coronavirus. Elsevier has granted permission to make all COVID-19-related research available in PubMed Central and other public repositories, allowing unrestricted reuse and analysis with proper attribution. The article discusses the consequences of isolating the elderly population during the COVID-19 pandemic. Social isolation poses significant health risks, including increased vulnerability to cardiovascular, autoimmune, neurocognitive, and mental health issues. Urgent measures are needed to mitigate these effects, such as providing social support through online technologies, frequent telephone contact, and community outreach projects. While isolation can reduce transmission, it must be carefully timed to avoid increasing the morbidity associated with affective disorders, particularly in disadvantaged and marginalized populations.The COVID-19 Resource Centre, established by Elsevier in January 2020, provides free information in English and Mandarin on the novel coronavirus. Elsevier has granted permission to make all COVID-19-related research available in PubMed Central and other public repositories, allowing unrestricted reuse and analysis with proper attribution. The article discusses the consequences of isolating the elderly population during the COVID-19 pandemic. Social isolation poses significant health risks, including increased vulnerability to cardiovascular, autoimmune, neurocognitive, and mental health issues. Urgent measures are needed to mitigate these effects, such as providing social support through online technologies, frequent telephone contact, and community outreach projects. While isolation can reduce transmission, it must be carefully timed to avoid increasing the morbidity associated with affective disorders, particularly in disadvantaged and marginalized populations.