The article discusses the immune responses to SARS-CoV-2 infection, which can be divided into three stages: an asymptomatic incubation period, a non-severe symptomatic period, and a severe respiratory symptomatic period. The authors highlight the challenges in managing asymptomatic carriers and the role of genetic factors in individual variations in immune response. They emphasize the importance of boosting immune responses during the early stages and suppressing inflammation in the severe stages. The article also explores the cytokine storm and lung damage associated with severe cases, suggesting that blocking IL-6, IL-1, and TNF may be beneficial. Additionally, it discusses the potential of using mesenchymal stromal/stem cells (MSCs) and vitamin B3 to manage lung damage. The role of HLA haplotypes in susceptibility to SARS-CoV-2 infection is also examined, and the potential of hyaluronan (HA) as a cause of fatalities in severe cases is highlighted. The authors propose simple interventions, such as using hyaluronidase and 4-MU to reduce HA accumulation and improve lung function.The article discusses the immune responses to SARS-CoV-2 infection, which can be divided into three stages: an asymptomatic incubation period, a non-severe symptomatic period, and a severe respiratory symptomatic period. The authors highlight the challenges in managing asymptomatic carriers and the role of genetic factors in individual variations in immune response. They emphasize the importance of boosting immune responses during the early stages and suppressing inflammation in the severe stages. The article also explores the cytokine storm and lung damage associated with severe cases, suggesting that blocking IL-6, IL-1, and TNF may be beneficial. Additionally, it discusses the potential of using mesenchymal stromal/stem cells (MSCs) and vitamin B3 to manage lung damage. The role of HLA haplotypes in susceptibility to SARS-CoV-2 infection is also examined, and the potential of hyaluronan (HA) as a cause of fatalities in severe cases is highlighted. The authors propose simple interventions, such as using hyaluronidase and 4-MU to reduce HA accumulation and improve lung function.