Elsevier established a free COVID-19 resource centre in January 2020, offering information in English and Mandarin. The centre grants permission for free access to its research in PubMed Central and other repositories. A systematic review of 43 studies found that patients with COVID-19 had high levels of post-traumatic stress symptoms (PTSS) and depressive symptoms. Patients with pre-existing mental health conditions reported worsening symptoms. Healthcare workers experienced increased depression, anxiety, and poor sleep quality. The general public showed lower psychological well-being and higher anxiety and depression levels compared to before the pandemic. Risk factors for mental health issues included female gender, poor self-rated health, and having relatives with COVID-19. The review highlights the need for further research on the direct and indirect mental health impacts of the pandemic to improve treatment and prevention strategies. The study also notes the potential neurotropic effects of SARS-CoV-2, with evidence of neurological symptoms and possible brain involvement. The pandemic has significantly affected mental health, particularly among healthcare workers and the general public, with long-term psychological effects expected. The review emphasizes the importance of understanding these impacts to better address mental health needs during future pandemics.Elsevier established a free COVID-19 resource centre in January 2020, offering information in English and Mandarin. The centre grants permission for free access to its research in PubMed Central and other repositories. A systematic review of 43 studies found that patients with COVID-19 had high levels of post-traumatic stress symptoms (PTSS) and depressive symptoms. Patients with pre-existing mental health conditions reported worsening symptoms. Healthcare workers experienced increased depression, anxiety, and poor sleep quality. The general public showed lower psychological well-being and higher anxiety and depression levels compared to before the pandemic. Risk factors for mental health issues included female gender, poor self-rated health, and having relatives with COVID-19. The review highlights the need for further research on the direct and indirect mental health impacts of the pandemic to improve treatment and prevention strategies. The study also notes the potential neurotropic effects of SARS-CoV-2, with evidence of neurological symptoms and possible brain involvement. The pandemic has significantly affected mental health, particularly among healthcare workers and the general public, with long-term psychological effects expected. The review emphasizes the importance of understanding these impacts to better address mental health needs during future pandemics.