Cadherins are essential for tissue morphogenesis during development, playing roles in cell adhesion, sorting, and tissue organization. They include classical, protocadherins, and atypical cadherins. Classical cadherins, such as E-cadherin, N-cadherin, and VE-cadherin, are involved in cell-cell adhesion and are crucial for tissue polarity and boundary formation. Their function is regulated by interactions with the actin cytoskeleton and signaling pathways, including β-catenin and p120. Protocadherins, primarily expressed in the nervous system, have diverse roles in cell organization and development, with their functions involving signaling and cell sorting. Atypical cadherins, such as Dachsous, Fat, and Flamingo, are involved in planar cell polarity (PCP) signaling, regulating cell movement and orientation. These cadherins interact with various proteins and signaling pathways to modulate tissue development and morphogenesis. Defective cadherin expression is linked to diseases, including cancer. The regulation of cadherin expression and activity involves transcriptional control, post-transcriptional modifications, and interactions with the cytoskeleton. Understanding the roles of different cadherin subtypes is crucial for elucidating the mechanisms of tissue development and disease.Cadherins are essential for tissue morphogenesis during development, playing roles in cell adhesion, sorting, and tissue organization. They include classical, protocadherins, and atypical cadherins. Classical cadherins, such as E-cadherin, N-cadherin, and VE-cadherin, are involved in cell-cell adhesion and are crucial for tissue polarity and boundary formation. Their function is regulated by interactions with the actin cytoskeleton and signaling pathways, including β-catenin and p120. Protocadherins, primarily expressed in the nervous system, have diverse roles in cell organization and development, with their functions involving signaling and cell sorting. Atypical cadherins, such as Dachsous, Fat, and Flamingo, are involved in planar cell polarity (PCP) signaling, regulating cell movement and orientation. These cadherins interact with various proteins and signaling pathways to modulate tissue development and morphogenesis. Defective cadherin expression is linked to diseases, including cancer. The regulation of cadherin expression and activity involves transcriptional control, post-transcriptional modifications, and interactions with the cytoskeleton. Understanding the roles of different cadherin subtypes is crucial for elucidating the mechanisms of tissue development and disease.