Cadherins in development: cell adhesion, sorting, and tissue morphogenesis

Cadherins in development: cell adhesion, sorting, and tissue morphogenesis

2006 | Jennifer M. Halbleib and W. James Nelson
The article reviews the roles of cadherins, a family of cell adhesion proteins, in developmental processes. Cadherins, including classical, protocadherins, and atypical cadherins, play crucial roles in cell adhesion, sorting, and tissue morphogenesis. Classical cadherins, the first identified type, mediate strong cell-cell adhesion and are involved in various developmental processes such as cell sorting, coordinated cell movements, and the orientation of cell division. Protocadherins, primarily expressed in the nervous system, have weak adhesive properties and are involved in tissue development and cell signaling. Atypical cadherins, such as Dachsous, Fat, and Flamingo, are involved in planar cell polarity (PCP) signaling, which coordinates global spatial cues with cell movement and orientation during tissue morphogenesis. The article also discusses the structural organization, gene structure, and regulatory mechanisms of these cadherin subtypes, highlighting their diverse functions in developmental contexts.The article reviews the roles of cadherins, a family of cell adhesion proteins, in developmental processes. Cadherins, including classical, protocadherins, and atypical cadherins, play crucial roles in cell adhesion, sorting, and tissue morphogenesis. Classical cadherins, the first identified type, mediate strong cell-cell adhesion and are involved in various developmental processes such as cell sorting, coordinated cell movements, and the orientation of cell division. Protocadherins, primarily expressed in the nervous system, have weak adhesive properties and are involved in tissue development and cell signaling. Atypical cadherins, such as Dachsous, Fat, and Flamingo, are involved in planar cell polarity (PCP) signaling, which coordinates global spatial cues with cell movement and orientation during tissue morphogenesis. The article also discusses the structural organization, gene structure, and regulatory mechanisms of these cadherin subtypes, highlighting their diverse functions in developmental contexts.
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