Caloric restriction (CR) without malnutrition has been shown to delay aging and extend lifespan in various species, but its effects on resistance to illness and mortality in primates are less clear. A 20-year longitudinal study in rhesus monkeys at the Wisconsin National Primate Research Center found that moderate CR significantly reduced the incidence of aging-related deaths and delayed the onset of age-associated pathologies such as diabetes, cancer, cardiovascular disease, and brain atrophy. The study, which began in 1989, involved 76 adult rhesus monkeys, with 30 initially and later expanded to include 30 females and 16 males. CR animals showed a 50% survival rate compared to 80% in the control group, and CR delayed the onset of age-related diseases. These findings suggest that CR can slow aging in primates, potentially offering insights into human aging and longevity.Caloric restriction (CR) without malnutrition has been shown to delay aging and extend lifespan in various species, but its effects on resistance to illness and mortality in primates are less clear. A 20-year longitudinal study in rhesus monkeys at the Wisconsin National Primate Research Center found that moderate CR significantly reduced the incidence of aging-related deaths and delayed the onset of age-associated pathologies such as diabetes, cancer, cardiovascular disease, and brain atrophy. The study, which began in 1989, involved 76 adult rhesus monkeys, with 30 initially and later expanded to include 30 females and 16 males. CR animals showed a 50% survival rate compared to 80% in the control group, and CR delayed the onset of age-related diseases. These findings suggest that CR can slow aging in primates, potentially offering insights into human aging and longevity.