Campylobacter jejuni is a leading cause of gastroenteritis globally, more prevalent than infections from Salmonella, Shigella, and E. coli O157:H7. In developed countries, it peaks in infancy and early adulthood, primarily acquired through poultry consumption. Symptoms include diarrhea, fever, and abdominal cramps, with stool cultures being the best diagnostic method. A concerning trend is the rise of antimicrobial-resistant strains, linked to antibiotic use in livestock. Most infections are self-limiting, and antibiotics are rarely needed. Guillain-Barré syndrome is a rare post-infectious complication, with a low incidence. Prevention involves proper food handling and cooking, avoiding unpasteurized milk, and maintaining good hygiene. In developing countries, Campylobacter is a major cause of childhood diarrhea and a common cause of traveler's diarrhea. It is the most common bacterial cause of diarrhea worldwide. The organism is a gram-negative, curved bacillus that grows slowly and is resistant to cephalothin. Diagnosis is confirmed by stool cultures, though PCR is not yet standard. Resistance to fluoroquinolones is increasing globally, driven by antibiotic use in food animals. Erythromycin is now considered the optimal treatment due to its low resistance rates and safety profile. Prevention focuses on reducing poultry contamination, improving food safety practices, and limiting antibiotic use in livestock. Person-to-person transmission is rare, but careful food handling and avoiding unpasteurized products are crucial for prevention.Campylobacter jejuni is a leading cause of gastroenteritis globally, more prevalent than infections from Salmonella, Shigella, and E. coli O157:H7. In developed countries, it peaks in infancy and early adulthood, primarily acquired through poultry consumption. Symptoms include diarrhea, fever, and abdominal cramps, with stool cultures being the best diagnostic method. A concerning trend is the rise of antimicrobial-resistant strains, linked to antibiotic use in livestock. Most infections are self-limiting, and antibiotics are rarely needed. Guillain-Barré syndrome is a rare post-infectious complication, with a low incidence. Prevention involves proper food handling and cooking, avoiding unpasteurized milk, and maintaining good hygiene. In developing countries, Campylobacter is a major cause of childhood diarrhea and a common cause of traveler's diarrhea. It is the most common bacterial cause of diarrhea worldwide. The organism is a gram-negative, curved bacillus that grows slowly and is resistant to cephalothin. Diagnosis is confirmed by stool cultures, though PCR is not yet standard. Resistance to fluoroquinolones is increasing globally, driven by antibiotic use in food animals. Erythromycin is now considered the optimal treatment due to its low resistance rates and safety profile. Prevention focuses on reducing poultry contamination, improving food safety practices, and limiting antibiotic use in livestock. Person-to-person transmission is rare, but careful food handling and avoiding unpasteurized products are crucial for prevention.