Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

462, 739–744 (2010) | Lenny Dang, David W. White, Stefan Gross, Bryson D. Bennett, Mark A. Bittinger, Edward M. Driggers, Valeria R. Fantin, Hyun Gyung Jang, Shengfang Jin, Marie C. Keenan, Kevin M. Marks, Robert M. Prins, Patrick S. Ward, Katharine E. Yen, Linda M. Liau, Joshua D. Rabinowitz, Lewis C. Cantley, Craig B. Thompson, Matthew G. Vander Heiden & Shinsan M. Su
This addendum to the article "Cancer-associated IDH1 mutations produce 2-hydroxyglutarate" by Dang et al. (2010) discusses the accumulation of R(−)-2-hydroxyglutarate (2HG) in tumors due to somatic mutations in IDH1. The authors propose that the accumulation of 2HG may drive oncogenesis by inducing redox stress through impairment of the respiratory chain, which is consistent with the latency observed in glioma development and the age-related increase in incidence of gliomas. They acknowledge that other mechanisms may also contribute to tumor formation. Further research has confirmed the association between abnormal 2HG production and tumors bearing mutations in either IDH1 or IDH2. The group continues to investigate the mechanistic link between 2HG accumulation and cancer formation, including the role of different stereoisomers of 2HG in promoting malignancy.This addendum to the article "Cancer-associated IDH1 mutations produce 2-hydroxyglutarate" by Dang et al. (2010) discusses the accumulation of R(−)-2-hydroxyglutarate (2HG) in tumors due to somatic mutations in IDH1. The authors propose that the accumulation of 2HG may drive oncogenesis by inducing redox stress through impairment of the respiratory chain, which is consistent with the latency observed in glioma development and the age-related increase in incidence of gliomas. They acknowledge that other mechanisms may also contribute to tumor formation. Further research has confirmed the association between abnormal 2HG production and tumors bearing mutations in either IDH1 or IDH2. The group continues to investigate the mechanistic link between 2HG accumulation and cancer formation, including the role of different stereoisomers of 2HG in promoting malignancy.
Reach us at info@study.space
Understanding Cancer-associated IDH1 mutations produce 2-hydroxyglutarate